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THE INFLUENCE OF STEROID HORMONES OF ADRENAL GLAND CORTEX ON THE FUNCTIONAL STATE OF HYPOPHISIAL-thyroidal SYSTEM OF PATIENTS WITH BRONCHIAL ASTHMA

Abstract

The aim of the work is to define the character and intensity of mutually mediated influence of steroids on the functional activity of hypophysial-thyroidal system in patients with bronchial asthma. 54 patients with uncontrolled bronchial asthma and 12 healthy people without clinical and ultrasonic manifestations of thyroid gland pathology took part in the research. The examination was held 24 hours later after standard cold bronchoprovocation test. The concentration of thyroid stimulating hormone, total thyroxin, total triiodothyronine, free fractions of these hormones, cortisol, dehydroepiandrosterone-sulfate was fixed in the blood serum by immune-enzyme analysis. It is established that 72% of patients with uncontrolled bronchial asthma as a response to cold stimulus had a drop of total and free thyroxin, a fall of free triiodothyronine level which is associated with bronchi responsiveness and which is independent from thyroid stimulating hormone quantity. Identified features of thyroid gland functional activity are closely connected with a high stress-induced level of glucocorticosteroids and a low effect of dehydroepiandrosterone-sulfate which limits stress-responsiveness.

About the Authors

Tat'yana A. Mal'tseva
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation


Viktor P. Kolosov
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation


Alexey B. Pirogov
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation


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Review

For citations:


Mal'tseva T.A., Kolosov V.P., Pirogov A.B. THE INFLUENCE OF STEROID HORMONES OF ADRENAL GLAND CORTEX ON THE FUNCTIONAL STATE OF HYPOPHISIAL-thyroidal SYSTEM OF PATIENTS WITH BRONCHIAL ASTHMA. Bulletin Physiology and Pathology of Respiration. 2012;(44):41-45.

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ISSN 1998-5029 (Print)