THE INFLUENCE OF ARGININDEHYDROGENASE ACTIVITY ON THE LEVEL OF HISTAMINE IN THE PERIPHERAL BLOOD OF PREGNANT WOMEN WITH HERPES VIRUS INFECTION

Abstract

The aim of the work is the study of arginindehydrogenase activity effect on the level of histamine in the peripheral blood of pregnant women with herpes-virus infection. 25 pregnant women who suffered an exacerbation of herpes virus infection in the third trimester of gestation and 10 healthy mothers were examined. A new histochemical methodology of arginindehydrogenase identification was developed. The activity of the enzyme in syncitiotrophoblast was calculated with the computer cytophotometry. It was established that in the syncitiotrophoblast of placental villi of the pregnant woman, who was under the influence of toxic products of exacerbating herpes virus infection with antibody titer growth of G class to herpes virus 1:12800, there was an increase of arginindehydrogenase activity identified by histochemical method till 48.7±2.9 standard units. At the same time in the peripheral blood a sharp growth of histamine content till 1.44±0.09 mkmole/l (in the control group it was 0.612±0.01 mkmole/l, р<0.001) was found out by biochemical method. The increase of histamine in the peripheral blood contributes to the development of fetoplacental insufficiency in pregnant women.