STATE OF LIPID SYNTHESIS FUNCTION OF LIVER AT MODERATE CEREBRAL ISCHEMIA IN NEWBORNS FROM MOTHERS WITH CYTOMEGALOVIRUS INFECTION

The contents of total cholesterol, high-density lipoproteins, low-density lipoproteins, and triglycerides in cord blood were studied at moderate cerebral ischemia in 230 mature newborns from mothers with chronic cytomegalovirus infection (CMVI) in the second trimester of gestation (main group). The first group (control group) consisted of 30 newborns from mothers with physiological pregnancy. Depending on the activity of chronic CMVI, 4 groups were distinguished, in each of which there were 2 subgroups. Subgroup A included newborns from mothers with pregnancy and an uncomplicated threat of miscarriage, and in subgroup B there were the patients whose mothers suffered the threat of miscarriage at 16-21^st week of gestation. The second group was represented by 50 newborns whose mothers had a latent course of chronic CMVI. The third group included 50 children from mothers with reactivation of chronic CMVI (titers of IgM antibodies to CMV were 1:200-1:400, IgG antibody titers to CMVI were 1:200-1:400, avidity index of IgG antibodies to CMVI was more than 65%). The fourth group included 50 newborns whose mothers suffered an acute phase of chronic CMVI (titers of IgM antibodies to CMV were 1:200-1:400, IgG antibody titers to CMV were 1:200-1: 800, avidity index of IgG antibodies to CMV was more than 65%), and in the fifth group there were 50 patients with antenatal history with reactivation of chronic CMVI (IgM antibody titers to CMV were 1:200-1:400, IgG antibody titers to CMV were 1:400-1:1600, avidity index of IgG antibodies to CMV was more than 65%). When comparing 2A and 2B subgroups with the first group, there were no significant changes in total cholesterol of high and low density lipoproteins and triglycerides. In children in 3A subgroup, the concentration of low density lipoproteins decreased to 0.34±0.02 mmol/L, and in 3B subgroup to 0.32±0.02 mmol/L with simultaneous increase in the triglyceride level to 0.51±0.03 mmol/L (in the first group, it was 0.53±0.03 mmol/L, p<0.001 and 0.43±0.03 mmol/L, p<0.05, respectively). In comparison with the first group in 5B subgroup, the lowest total cholesterol values (1.82±0.05 mmol/L, p<0,05), low-density lipoproteins (0.21±0.05 mmol/L, p<0.001), as well as high triglycerides (0.59±0.03, p<0.001) were registered. These can weaken the compensatory-adaptive reactions of the hormonal system that regulates the immune response, vascular permeability and the blood-brain barrier, as well as disrupt the blood supply to the brain in newborns with moderate cerebral ischemia.

lipids, liver, moderate cerebral ischemia, mature newborns, cytomegalovirus infection

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