NEURO-HUMORAL-HORMONAL REGULATION OF IMMUNE RESPONSE IN PREGNANT WOMEN WITH HERPES VIRUS INFECTION

The aim of the research is the study of neuro-humoral-hormonal regulation of the immune response in pregnant women with exacerbation of herpes virus infection. 55 pregnant women at the age of 18-35 with exacerbation of herpes-virus infection at different stages of gestation (the main group) and 30 practically healthy pregnant women (the control group) were examined. In the peripheral blood by the method of solid phase immune-enzyme analysis the antibodies to the virus of simple herpes of the first type, interferons (IFN-α, γ), interleukins (IL-1, 2, 4, 8), tumor necrosis factor (TNF-α), placental hormones, as well as biologically active substances (serotonin) were identified. At the exacerbation of herpes-virus infection the quantity of serotonin in the peripheral blood is high at the beginning of pregnancy which is three times higher than in healthy pregnant women and this level does not change during all the period of gestation. In the main group there is the decrease of lymphocytes with suppressor activity at all stages of gestation especially if the exacerbation occurs in its first half (СD8⁺Т-lymphocytes drop till 6-9% (in the control group 20-25%), and subpopulation of СD4⁺Т-lymphocytes drops by 10-15%. Even at low activation of infection (antibody titer 1:3200) the activity of NK-lymphocytes increases in 1.5 times, and at the growth of antibody titer there is six times rise of the percentage of CD25⁺-cells in comparison with the control group, which proves a high differentiation of B-lymphocytes in plasmatic cells. The dependence of the parameters of cell and humoral responses of the immunity on hormonal changes at different antibody titer to herpes virus (1:1600-1:12800) is revealed. The lack of estradiol and estriol becomes the basic criterion of immune system consistency risk in the peripheral blood of pregnant women. The rise of the anti-inflammatory cytokines level (IL-1, IL-8, TNF-α) leads to the change of cytokine balance and to the disturbance of immunologic regulation mechanism which is revealed through the drop of immune suppressive activity.

herpes virus infection, pregnancy, hormones, cytokines, immunity

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