THE ACTIVITY OF GLYCOSYLTRANSFERASE IN SYNCYTIOTROPHOBLAST OF PLACENTA VILLI AT THE EXACERBATION OF CYTOMEGALOVIRUS INFECTION DURING GESTATION

The aim of the work is to find out the activity of glycosyltransferase in the syncytiotrophoblast of placenta villi of parturient women who suffered the exacerbation of cytomegalovirus infection during the third trimester of gestation. 25 placentas of parturient women at the age of 18-25 with chronic cytomegalovirus infection in exacerbation (the main group) and 20 placentas from pregnant women without the above-mentioned pathology (the control group) were examined. The chronic cytomegalovirus infection exacerbation was diagnosed at the presence of IgM antibodies or 4-times and more growth of IgG antibodies titer in the paired serums within the dynamics of 10 days, at the presence of avidity index more than 50% as well as of cytomegalovirus DNA detection. Glycosyltransferase which contributes to the transference of glycosyl groups from uridinediphosphateglucose was found with the histochemical method in the syncytiotrophoblast by T.Takeuchi and G.G.Glenner. UDP-glycosodehydrogenase was found by Z.Lojda method. The estimation of enzymes activity was done by computer cytophotometry. It was found out that the exacerbation of cytomegalovirus infection with antibody titer 1:800 leads to glycosyltransferase oppression in the syncytiotrophoblast of placenta villi, which is proved by three times drop of cytophotometric parameter in the main group in comparison with the control one. There is also a suppression of uridinediphosphatedehydrogenase activity that participates in the synthesis of glycosaminoglycans of the maternal part of placenta (1.6 times drop of cytophotometric parameter in the main group in comparison with the control one), and hence there is the decrease of heparin content which maintains anticoagulation effect in the lacunar blood during pregnancy.

цитомегаловирусная инфекция, глюкозилтрансфераза, уридинфосфатдегидрогеназа, плацента, cytomegalovirus infection, glycosyltransferase, uridinediphosphatedehydrogenase, placenta

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