COURSE OF PREGNANCY IN WOMEN WITH ACUTE CHRONIC CYTOMEGALOVIRUS AND HERPESVIRUS INFECTION

Abstract

The aim of the research is to study the role of chronic cytomegalovirus and chronic herpesvirus infections in the formation of placental insufficiency in pregnant women. 116 pregnant women with exacerbation of chronic cytomegalovirus and herpesvirus infection (the main group) and 40 women without exacerbation (the control group) were examined. This paper presents the data about the course of pregnancy, complications, changes in ultrasound pictures, hormones at acute cytomegalovirus and herpesvirus infection. The study found that in the main group there was an increase of 50% frequency of threatening spontaneous abortion, premature births; 30% of pregnant women with exacerbation of chronic cytomegalovirus and herpesvirus infection had acute infectious diseases of the upper respiratory tract. At exacerbations of cytomegalovirus and herpesvirus infection during pregnancy in the venous blood serum there was 1.5 times reduction of β-hCG, 1.8 times reduction of progesterone in comparison with the control group, which is the marker of primary placental insufficiency. The decrease of estriol level by more than 50% and of hCG (1.2 times) illustrates the development of chronic placental insufficiency, the risk of fetal malnutrition and hypoxia. The ultrasound examination of pregnant women of the main group showed the signs of intrauterine infection of the fetus (ventriculomegaly, increased trabecularventricles, the presence of inclusions in the atrial septum, the change in the quantity of amniotic fluid). Sonographic signs of primary placental insufficiency have been found in 22% of cases and of chronic placental insufficiency in 30% of pregnant women in the main group.