CHORION FORMATION PEQULIARITIES IN WOMEN WITH HYPOTHALAMUS DYSFUNCTION

The pregnancy in women with hypothalamus dysfunction is concomitant with the multiple increase of the risk of placental insufficiency development and early pregnancy failure. The aim of the research is the study of chorion morphological changes in women with hypothalamus dysfunction depending on the fact whether there was the correction of hypothalamus dysfunction before pregnancy or not. The main group included 90 pregnant women who had the treatment of this pathology before pregnancy; the group of comparison consisted of 115 pregnant women with hypothalamus dysfunction who did not have such a therapy (they were included into research in the first trimester), and the control group had 50 practically healthy women. Two pregnant women from the main group were aborted by their own wish at 7-8 weeks of gestation, there were 10 such-like patients in the control group and 12 women from the group of comparison had a spontaneous abortion at 7-9 weeks of pregnancy. In all cases the morphological study of chorion was done with electronic-microscopic and histological methods. As a result of morphological study of the women from the main group after treatment the changes of chorion were found in the form of insufficiency of adaptive and compensatory processes revealed at the level of the blood channel of terminal and interim villi through dystrophic changes of syncytiotrophoblast elements of villi stroma. The mentioned morphological changes contributed to the disturbance of diffuse and synthetic function of placenta and to the development of initial placental insufficiency in 23.9% of women examined in the main group, which proves the fact that despite pregravidar preparation there are villous chorion changes in women with hypothalamus dysfunction. The treatment of hypothalamus dysfunction before pregnancy allows to lower the frequency of pregnancy complications almost twice as much but it does not exclude them completely. 10.4% of women with hypothalamus dysfunction who did not have the correction of this pathology had a spontaneous abortion. It was conditioned by intensive dystrophic changes of cell elements of trophoblast (syncytiotrophoblast, cytotrophoblast, fibrose stroma), microcirculatory channel, which dominated over compensatory and adaptive processes.

дисфункция гипоталамуса, морфология плаценты, плацентарная недостаточность, hypothalamus dysfunction, placenta morphology, placental insufficiency

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