THE COMPOSITION OF FATTY ACIDS OF ERYTHROCYTE MEMBRANES IN PATIENTS WITH CHRONIC BRONCHOPULMONARY DISEASES
Abstract
The composition of fatty acids of erythrocyte membranes in patients with chronic non-obstructive bronchitis (CNB) and chronic obstructive pulmonary disease (COPD) in remission was studied. A total of 40 people, including 15 patients with CNB and 15 patients with COPD of a mild stable course were examined. The control group included 10 healthy people. The activity of the inflammatory process was studied as non-specific immunity, cytokine status. The fatty acid composition of erythrocyte membranes was studied by gas-liquid chromatography. In both groups of examined patients with bronchopulmonary pathology a significant accumulation of saturated fatty acids (14:0, 15:0, 18:0) was found out. In patients with CNB there was an increase of the content of arachidonic acid (20:4n6) by 15% (p<0.05), in patients with COPD it was by 41% (p<0.001) compared to healthy people. High levels of polyunsaturated fatty acids of n6 family in the membrane of red blood cells in patients with chronic lung diseases indicates an increase in the substrate for the formation of inflammatory mediators (leukotriene B4), and bronchospasm (prostaglandin D2). The level of eicosapentaenoic acid (20:5n3) was reduced by 24% (p <0.05) in patients with CNB, in patients with COPD it was twice as low as the initial one (p<0.001). The observed increase in the ratio 20:4n6/20: 5n3 that was 1.5 times higher (p<0.001) in patients with CNB and 3 times higher in patients with COPD may be a specific marker of poor prognosis of bronchopulmonary pathology and chronic inflammation development. Thus, the development of chronic respiratory diseases is accompanied by a disturbance of fatty acid composition of erythrocyte membranes, and the imbalance between the substrates for synthesis of pro- and anti-inflammatory eicosanoids.
About the Authors
Tatʹyana P. Novgorodtseva
Research Institute of Medical Climatology and Rehabilitation Treatmen
Russian Federation
Russian Federation
Yuliya K. Karaman
Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
Vera V. Knyshova
Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
Natalia V. Zhukova
Institute of Marine Biology of Far East Branch RAS
Russian Federation
Russian Federation
Natalia V. Bival'kevich
Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
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For citations:
Novgorodtseva T.P., Karaman Yu.K., Knyshova V.V., Zhukova N.V., Bival'kevich N.V. THE COMPOSITION OF FATTY ACIDS OF ERYTHROCYTE MEMBRANES IN PATIENTS WITH CHRONIC BRONCHOPULMONARY DISEASES. Bulletin Physiology and Pathology of Respiration. 2013;(48):33-38. (In Russ.)
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