THE STATE OF LOCAL SPECIFIC PROTECTION AND CELLULAR IMMUNITY IN WOMEN OF CHILDBEARING AGE AT INFLUENZA A(H1N1) SWL COMPLICATED WITH COMMUNITY-ACQUIRED PNEUMONIA

The study of local non-specific protection and cellular immunity at influenza A(H1N1) swl in 50 women of childbearing age was done. 20 patients were diagnosed to have a community-acquired pneumonia (the main group), 30 women at the moment of examination did not have any acute infectious diseases and the exacerbation of chronic somatic and gynecological pathology (the control group). The verification of influenza virus A(H1N1) swl was conducted in the paired blood sera obtained from the patients at the moment of their getting into the in-patients hospital and in 10 days after that at the four-times growth of antibodies titer to the pathogen in the reaction of hemagglutination inhibition. The study of secretory immunoglobulin A (slgA) content in the blood serum was carried out with the immune-enzyme analysis, the percentage of populations and subpopulations of lymphocytes was done with the flow cytofluorimetry method. It was found out that the influenza A(H1N1) swl complicated with community-acquired pneumonia is characterized with the intensive intoxication syndrome which determines the changes of immunologic resistance of a female organism. The patients of the main group in comparison with the control group were registered to have the fall of sIgA level (2.6±0.29 and 4.8±0/.58 mg//l, respectively, р<0.001), which proved a lower level of the local immune protection of their upper airways and the tracheobronchial tree. In the main group there was a decrease of a relative quantity of T-lymphocytes (CD3+) till 65.6±1.57% (in the control group it was till 71.2±1.63%, р<0.05) predominantly due to Т- suppressors (СD8+) it was till 18.1±1.05% (in the control group it was till 23.7±0.66%, p<0.01) at the absence of a reliable change of a number of natural killers (CD16+56+), which may reduce the effectiveness of antiviral immunity. At the same time the women from the main group in comparison with the women from the control group had an increase of B-lymphocytes (CD19+) till 18.8±0.68% (in the control group it was till 14.6±0.73%, р<0.001) which participate in the humoral immune response of the female organism to the virus aggression against intensive intoxication syndrome.

местная и общая иммунная защита, женщины детородного возраста, грипп А(Н1N1) swl, внебольничная пневмония, local and general immune protection, women of the childbearing age, influenza A(H1N1) swl, community-acquired pneumonia

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