MEMBRANE FATTY ACIDS TRANSPORT (REVIEW)
Abstract
Docosahexaenoic and arachidonic acids are extremely important for the normal fetus growth during pregnancy. As they cannot be synthesized by a fetus and placenta, the fetus gets them from mother’s blood through placenta transportation. The literature review deals with the mechanism of long-chained fatty acids transportation mechanism which occurs in two ways: passive diffusion through the membrane and transportation with the special proteins. The latter are presented by FABPpm/GOT2, FABP, FATP, caveolin-1 and FAT/CD36. A big part of the article is devoted to the features of fatty acids transportation at pregnancy. It includes three stages: dissociation with the protein complex, transportation through plasmatic membrane and their binding with intracellular proteins. pFABPpm localized on the plasmatic membrane of the maternal side of placenta, FATP-1 and FATP-4 play an important role in the selective transportation of docosahexaenoic and arachidonic acids. FABP directs fatty acids into different points inside syncytiotrophoblast or into umbilical cord plasma. The conclusion was made about the fact that the transportation of long-chained fatty acids to the fetus is the result of a number of processes which occur in a mother and in a fetoplacental complex.
About the Authors
Inna V. Dovzhikova
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation
Russian Federation
Mikhail T. Lutsenko
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation
Russian Federation
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Dovzhikova I.V., Lutsenko M.T. MEMBRANE FATTY ACIDS TRANSPORT (REVIEW). Bulletin Physiology and Pathology of Respiration. 2013;(50):130-138. (In Russ.)
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