PECULIARITIES OF PROAND ANTIOXIDANT STATUS OF BLOOD SERUM IN BRONCHIAL ASTHMA PATIENTS WITH VARIED SENSITIZATION

Abstract

The paper deals with the research of peculiarities of pro- and antioxidant status of blood serum in 92 bronchial asthma patients with varied sensitization. The research shows that the increase in prooxidant activity of asthma patients blood serum occurs against the background of decrease in its antioxidant activity; salience of both processes varies in correlation with the sensitization variant. As it has been found out, prooxidant activity increase in asthma patients blood serum is accompanied by the rise of malone dialdehyde content, while the decrease in antioxidant activity is accompanied by the fall of the α-tocoferol - a fat-dissolved antioxidant (obvious with fungi- and polyvalent sensitization). Minimal growth of ratio coefficient of prooxidant and antioxidant activity of blood serum in comparison with healthy donors was found in patients with bronchial asthma with sensitization by domestic allergens (in 2 times, p<0.01), and the maximal growth was in patients with fungi- and polyvalent sensitization (in 6.3 and 6.5 times, respectively, p<0.01). Judging by the change in the coefficient of prooxidant-antioxidant activity proportion in blood serum, the strongest oxidation stress occurred among asthma patients with mycogenic and polyvalent sensitization, whereas the weakest one was observed in asthma patients with allergies both to house dust and to pollens. The degree of oxidation stress determines the severity of the disease course.