THE FEATURES OF OXYGEN EXCHANGE BETWEEN A MOTHER AND A FETUS UNDER THE RELAPSE OF HERPESVIRUS INFECTION IN THE THIRD TRIMESTER OF PREGNANCY

Abstract

The articles shows the features of the oxygen exchange in 40 parturient women with the relapse of herpesvirus infection in the third trimester (antibody titer IgG 1:12800) and the causes of the decrease of transplacental transference of oxygen in the fetus blood. In erythrocytes of the peripheral blood of parturient women of this group there was a decrease of antioxidant properties of superoxide scavenger; the accumulation of lipid peroxidation products (TBA-active products, lysophosphatidylcholine) at high phospholipase activity aggravated the oxidative denaturation of main membrane proteins of cytoskeleton (spectrin, ankirin and protein 3 and 4.1), increased the microviscosity, lowered the membrane deformation and led to echinocytosis transformation of erythroid cells. There was the disturbance of the composition and properties of hemoglobin against this background. There was also the increase of thermolabile fraction, which at the high level of 2.3 diphosphoglyceric acid contributed to the decrease of oxyhemoglobin formation, рО₂ in blood and the transference of oxygen to placenta tissue. In the supernatant fluid of placenta homogenates from women of this group there was a decrease of heat-shock protein Hsp70 and proapoptotic protein Bcl-2, the increase of cytochrome C level and the activity of caspase-3, which led to the growth of the number of syntrophoblast nuclei in the condition of apoptosis. While studying the structure of fetoplacental barrier, the increase of synthesis of connective tissue fibre structures in the villi stroma was found out, which increased the distance from the basal syntrophoblast membrane to the vessels. The obtained results prove an important role of active herpesvirus infection in the disturbance of oxygen exchange between a mother and a fetus.