ENERGETIC STATUS OF ERYTHROCYTES IN THE BLOOD OF PREGNANT WOMEN UNDER THE RELAPSE OF CYTOMEGALOVIRUS INFECTION
Abstract
The aim of the research is to study morphofunctional changes at maturation of erythrocytes of the peripheral blood in pregnant women at the exacerbation of chronic cytomegalovirus infection (CMVI). The features of energetic exchange of blood erythrocytes of pregnant women with the relapse of CMVI at the 20-22 weeks of gestation were studied. The model which allows to estimate the degree of maturation and the character of biosynthetic activity of blood erythrocytes of pregnant women by the distribution of methylene blue in the membrane of cells was developed. The dependence of the character of erythrocytes painting was revealed: basophil/oxyphilous one depending on the cells maturation and intensiveness of oxidation-reduction processes. In the blood smear of pregnant women under the relapse of CMVI there was a growth of erythrocytes number (р<0.05) painted methylene blue, which proves the decrease of the activity of NADPH/disulphide reductase system. While conducting a biochemical study of blood erythrocytes in pregnant women of this group the suppression of the activity of energy-forming processes was found out, which was revealed in the hydrolysis of the significant part of the total (р<0.05) and bound to hemoglobin ATP (р<0.05). Against this background there was the change of the state of oxidative phosphorylation processes, which contributed to the disturbance of phosphates in the cell and was revealed through the growth of indices of the total (р<0.05) and nonorganic intra-erythrocyte phosphorus (р<0.05). The revealed changes in the energetic provision of erythrocytes under CMVI relapse can be the reason for the development of disturbances of blood rheology of pregnant women and its oxygen-transport properties.
About the Authors
Mikhail T. Lutsenko
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation
Russian Federation
Irina A. Andrievskaya
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation
Russian Federation
Olʹga L. Kutepova
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation
Russian Federation
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Review
For citations:
Lutsenko M.T., Andrievskaya I.A., Kutepova O.L. ENERGETIC STATUS OF ERYTHROCYTES IN THE BLOOD OF PREGNANT WOMEN UNDER THE RELAPSE OF CYTOMEGALOVIRUS INFECTION. Bulletin Physiology and Pathology of Respiration. 2014;(51):92-96. (In Russ.)
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