SUCCINATE CONTAINING DRUGS AND OXIDATIVE STRESS IN THE CONDITIONS OF ULTRAVIOLET RADIATION

Prolonged exposure of ultraviolet radiation on the human organism induces the development of critical condition accompanied by exhaustion of energy and other reserves, reduction of tissue metabolism. Stage development of consequences of ultraviolet radiation leads to hypoxia. It is known that in the base of any kind of hypoxia there is insufficiency of the main energy forming system of mitochondrial oxidative phosphorylation conditioned by considerable decrease of oxygen delivery to the tissues or inhibition of oxidative enzymes. At present in the clinical practice compounds of succinic acid having antioxidant and cytoprotective properties are used as pharmacological active substances with a wide range of biological activity. In experimental conditions the possibility to correct free radical lipid oxidation of rats’ organism membranes was studied with the introduction of the succinate containing drugs called Remaxol^® and Cytoflavin^® (Polysan, St. Petersburg). The animals were divided into 4 groups and each of them had 15 rats: intact animals which were held in standard conditions of vivarium; the control group in which rats were exposed to ultraviolet radiation during three minutes daily; the experimental group in which before ultraviolet radiation animals had a daily intake of the Remaxol in a dose of 50 mg/kg; the experimental group in which before ultraviolet radiation animals had a daily intake of the Cytoflavin in a dose of 50 mg/kg. It was found out that in the blood of experimental animals a daily ultraviolet radiation during three minutes contributes to the increase of lipid hydroperoxides level (by 26-48%), of diene conjugate (by 29-53%), and of malonic dialdehyde (by 40-62%) against the decrease of antioxidant system activity in the blood of intact animals. The introduction of the succinate containing drugs to rats in the conditions of ultraviolet radiation contributes to the reliable decrease in the blood of lipid hydroperoxides by 11-19%, of diene conjugates - by 14-20%, malonic dialdehyde - by 17-29% in comparison with the rats of the control group. While analyzing the effect of the succinate containing drugs on the activity of the components of antioxidant system it was shown that the level of ceruloplasmin in the blood of animals was reliably higher by 9-17%, of vitamin E by 11-26%, of catalase by 28-52% in comparison with the same parameters of the rats of the control group. So, the application of the succinate containing drugs called Remaxol and Cytoflavin in the conditions of ultraviolet radiation of the organism of animals under experiment leads to the stabilization of the processes of peroxidation against the increase of antioxidant system activity.

сукцинатсодержащие препараты, Ремаксол, Цитофлавин, ультрафиолетовое облучение, перекисное окисление липидов биологических мембран, продукты пероксидации (гидроперекиси липидов, диеновые конъюгаты, малоновый диальдегид), антиоксидантная система, succinate containing drugs, Remaxol, Cytoflavin, ultraviolet radiation, biological membranes lipid peroxidation, products of peroxidation (lipid hydroperoxides, diene conjugates, malonic dialdehyde), antioxidant system

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