MORPHOLOGICAL FEATURES OF RESPIRATORY SYSTEM UNDER DRUG-RESISTANT TUBERCULOSIS IN VIEW OF DURATION AND TYPE OF DRUG RESISTANCE

Abstract

The morphological changes in the respiratory system with drug-resistant fibro-cavernous pulmonary tuberculosis were studied. The material taken from 90 dead patients at the age of 25 to 70 years old, 36 of whom died of fibro-cavernous pulmonary tuberculosis with multidrug resistance, were examined. Those who died of fibro-cavernous tuberculosis with drug sensitivity became the control group. A number of features that characterize the morphological changes in the drug-resistant fibro-cavernous pulmonary tuberculosis were found out. They are revealed through the formation of giant caverns, significant increase in the volume density of caseous necrotic component, specific lesion of lobar and segmental bronchi in 96% of cases. In lymph nodes against hyperplasia of lymphoid tissue there is a dramatic atrophy of lymphoid follicles with the reduced number of T and B lymphocytes, which is a reduction of morphological features of cellular immunity. These changes are most conspicuous in groups with multidrug-resistance and multi-resistance at the duration of the disease from 1 to 5 years.