MALONDIALDEHYDE AND TUMOR NECROSIS FACTOR ALPHA AT CYTOMEGALOVIRUS INFECTION DURING PREGNANCY

Abstract

The purpose of this study was to investigate the activity of lipid peroxidation in relation to the content of the proinflammatory cytokine of tumor necrosis factor alpha (TNFα) at cytomegalovirus infection (CMVI) in the III trimester of gestation, depending on the titer of IgG antibodies to cytomegalovirus (CMV). A total of 60 pregnant women in the III trimester of gestation, aged 21-38 years, and diagnosed with chronic CMVI were examined. The patients of the main group were divided into two subgroups: subgroup A - 30 women with reactivation of CMVI (titer of IgG antibodies to CMV 1:1600), subgroup B - 30 women with a titer of IgG antibodies to CMV 1:800. The comparison group included 30 women with physiological pregnancy, comparable by gestational period and age with the main group. After the study we can conclude that the activation of peroxidation recorded by malondialdehyde (MDA) content in the blood serum of pregnant women with CMVI is associated with an increase in the concentration of proinflammatory cytokines - TNFα. These figures depend on the titer of IgG antibodies to CMV. When there is the titer of IgG antibodies to CMV 1:1600, the content of TNFα in peripheral blood of women became 2.7 times more (p<0.001), of MDA 1.8 times more (p<0.001); at titer of IgG antibodies to CMV 1:800 it was 1,5 times (p<0.001) and 1.3 times more (p<0,001), respectively. The data obtained allow us to suggest the possible accession of inflammatory complications and reasonable approach to the choice of tactics for pregnant women with CMVI, i.e. to conduct detoxification therapy.