THE STATE OF HEPATOBILIARY SYSTEM IN MODERATE CEREBRAL ISCHEMIA IN MATURE NEWBORNS FROM MOTHERS WITH CHRONIC CYTOMEGALOVIRUS INFECTION IN THE II TRIMESTER OF PREGNANCY

Using biochemical methods, the functional state of hepatobiliary system at moderate cerebral ischemia was studied in 115 mature newborns from mothers with chronic cytomegalovirus infection (CMVI) against chronic herpes-virus infection in the second trimester of pregnancy. The control was made of 30 healthy newborns, the group of comparison consisted of 25 newborns from mothers with chronic CMVI in II trimester of gestation (there was the absence of antibody titer of IgM to cytomegalovirus (CMV), IgG antibodies to CMV were 1:200 and avidity index IgG to CMV was 56-70%). In the newborns with moderate cerebral ischemia whose mothers had reactivation of chronic CMVI in II trimester of gestation (antibodies of IgG to CMV are 1:200-1:400, IgG antibodies to CMV are 1:200-1:800 and avidity index of IgG to CMV is 56-70%) in comparison with the control there was the decrease of the general protein till 54.2±1.10 g/L and albumins till 34.4±1.01 g/L against the increase of bilirubin concentration: of general one till 35.9±1.59 mcmole/L, of unconjugated one till 33.6±1.58 mcmole/L and of conjugated one till 2.27±0.10 mсmole/l (in the control group they are 60.9±1.39 g/L, р<0.001; 38.0±1.15 g/L, р<0.05; 25.4±1.67 mcmole/L, р<0.001; 23.3±1.66 mcmole/L, р<0.001; 1.87±0.09 mcmole/L, р<0.01, respectively), which suggested the inhibition of protein synthesis and inconsistency of pigment exchange. At the same time there was the increase of activity of alkaline phosphatase till 170.6±9.11 МЕ/L (in the norm it is 142.0±6.39 МЕ/L, р<0.05), which was typical for the development of cholestasis. Moderate cerebral ischemia in newborns from mothers with chronic CMVI reactivation (antibody titer of IgM to IgM CMV is 1:200-1:400, the growth of antibody titer of IgG to CMV is 1:400-1600 and avidity index of IgG to CMV is 56-70%) in comparison with the same perinatal pathology in babies from mothers with the exacerbation of the infection (the antibody titer of IgM to CMV is 1:200-1:400, the antibody titer of IgG to CMV is 1:400-800 and avidity index of IgG to CMV is 56-70%) led to the increase of alkaline phosphatase activity till 188.5±10.5 МЕ/L (р<0.05), which indicates more intensive cholestasis.

беременность, гепатобилиарная система, церебральная ишемия, доношенные новорожденные, хроническая цитомегаловирусная инфекция, pregnancy, hepatobiliary system, cerebral ischemia, mature newborns, chronic cytomegalovirus infection

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