CLINICAL AND PATHOMORPHOLOGICAL CHARACTERISTIC OF SEVERE CEREBRAL ISCHEMIA IN MATURE NEWBORNS WITH INTRAUTERINE PARAINFLUENZA OF 1 AND 3 TYPES AND MIXED-RESPIRATORY VIRUS INFECTION

The aim of the work is to give clinical and pathomorphological characteristic of severe cerebral ischemia in newborns with antenatal parainfluenza and mixed-respiratory virus infection. Echographic indices of the brain and the blood flow in the mean brain artery at severe cerebral ischemia were studied in 27 mature newborns; the composition of soft brain tunic, brain cortex, brain substances, ependymas and choroid plexus of lateral ventricle were examined in 14 dead babies with intrauterine parainfluenza of 1 and 3 types (the first group) and in 23 babies with mixed-respiratory virus infection (the second group). The control group included 30 healthy mature newborns and 25 newborns of 38-40 weeks with uncomplicated antenatal anamnesis who died from the birth trauma. It was found out that in the second group in comparison with the first group the frequency of central nervous system depression increased till 39.1% and in 34.8% of children there was subarachnoidal hemorrhage. In the first group such changes happened in 7.4% (р<0.05) and in 3.7% (р<0.05) of newborns, respectively. In the second group there was the increase of the vessel resistance in the medial cerebral artery till 0.79±0.03 relative units (in the first group it is 0.70±0.02 relative units, р<0.05). At antenatal mixed-respiratory virus infection there were intra ventricle hemorrhages with pathomorphological identification of liquid blood in the cavity of the front and back horns of lateral ventricles (in 3 newborns) as well as significant desquamation of ependymocytes. Died children often had vasculitis, perivascular hemorrhages, intensive plephora of capillary tubes with proliferation of their endotheliocytes in choroid plexus of lateral ventricles as a result of direct and indirect influence of several respiratory viruses on membrane structures of cellular elements.

новорожденные, церебральная ишемия, внутриутробный парагрипп, внутриутробная микст-респираторная вирусная инфекция, головной мозг, средняя мозговая артерия, infants, cerebral ischemia, intrauterine parainfluenza, intrauterine mixed-respiratory virus infection, brain, middle cerebral artery

1. Аксенов О.А., Осипова З.А. Роль нейраминидазы миксовирусов в системе интерфероногенеза // Вопр. вирусол. 1990. Т.35, №6. С.483-486.

2. Гориков И.Н., Костромина Н.О., Резник В.И. Клиническая характеристика церебральной ишемии у новорожденных от матерей, перенесших различные острые респираторные инфекции в период беременности // Дальневост. журн. инфекц. патол. 2010. №16. С.73-76.

3. Влияние обострения хронического необструктивного и обструктивного бронхита вирусной этиологии у женщин во II триместре беременности на состояние церебрального кровотока у их новорожденных / И.Н.Гориков [и др.] // Бюл. физиол. и патол. дыхания. 2012. Вып.46. С.48-51.

4. Григоренко А.А. Морфологические и гистохимические изменения эндокринных желез при сепсисе у детей: автореф. дис. … канд. мед. наук. Новосибирск, 1981. 19 с.

5. Поражение центральной нервной системы плодов и новорожденных при внутриутробной инфекции, вызванной респираторными вирусами / Б.А.Ерман [и др.] // Арх. патол. 1998. Т.60, №2. С.27-31.