THE ACTIVITY OF SH-GROUP IN SYNCYTIOTROPHOBLAST OF CHORION VILLI AT CYTOMEGALOVIRUS INFECTION
Abstract
The aim of the research is to define the state of SH-group activity in syncytiotrophoblast of chorion villi under the relapse of cytomegalovirus infection (CMVI) at the stage of pregnancy of 5-7 weeks. To estimate the activity of SH-group identified by Barrnett-Seligman method 15 villous chorions of 8-9 weeks obtained at the medical abortion from women with the relapse of CMVI (IgG antibody titer was 1:1600) at the stage of 5-7 weeks were studied. The control group included 15 villous chorions from CMV-seronegative women at the same stages of pregnancy. The analysis of paraffin section dyed by Barrnett-Seligman method was done by cytophotometric method by Scion program. As a result of the study the decrease of SH-group concentration was found out in the outer membrane of syncytiotrophoblast of chorion villi under CMVI relapse (IgG antibody titer was 1:1600) at the stage of 5-7 weeks till 10.6±0.4 arb. units (the control was 20.5±0.8 arb. units, p<0.001). Thus, the expression of CMV at the surface of chorion villi syncytiotrophoblast which is the most evident during the relapse of infection is associated with the decrease of SH-group concentration and the disturbance of trophic processes in fetoplacental barrier at the early stages of embryo development.
About the Author
Mikhail T. Lutsenko
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
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Review
For citations:
Lutsenko M.T. THE ACTIVITY OF SH-GROUP IN SYNCYTIOTROPHOBLAST OF CHORION VILLI AT CYTOMEGALOVIRUS INFECTION. Bulletin Physiology and Pathology of Respiration. 2015;(56):94-97. (In Russ.)
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