THE EFFECT OF COMPREHENSIVE REHABILITATION THERAPY ON THE INTERFERON STATUS IN PATIENTS WITH ASTHMA

Abstract

The effect of comprehensive rehabilitation therapy on the interferon status was studied in 57 patients with partially controlled and well-controlled asthma. The patients received base therapy: inhaled glucocorticosteroid combined with long-acting β₂-agonist. Additionally there were applied montelukast sodium (the leukotriene receptor blocker) and electrophoresis of mud extract on the chest area (10 treatment procedures). The duration of treatment was 30 days. We analyzed the levels and the ratio of basal and E. coli lipopolysaccharide-stimulated IFN-γ. Patients with asthma had a low basal IFN-γ during initial examination. Before treatment basal IFN-γ was below 4.3 pg/ml, compared with healthy volunteers which had 9.75 pg/ml. Patients receiving medical complex including electrophoresis mud squeezing, montelukast sodium and basic inhalation therapy had a basal IFN-γ 3.5 times higher compared with ones before treatment. Significant increase in stimulated IFN-γ by 49% was also observed. Ratio of basal and stimulated IFN-γ had also a statistically significant increase when compared to the values before and after treatment. It was shown that comprehensive treatment with inhalation therapy, antileukotriene therapy by montelukast sodium and pelotherapy (the electrophoresis of mud extract) is pathogenetically justified for patients with asthma. The treatment contributes to deviation of the immune response to Тh1 type and improve the functional and reserve capacities of the immune cells. The proposed comprehensive treatment helps to normalize the IFN-γ levels and enhance disease control.