CLINICAL-FUNCTIONAL CHARACTERISTIC OF MILD CEREBRAL ISCHEMIA IN MATURE NEWBORNS WITH INTRAUTERINE MONO- AND MIXED-INFLUENZA INFECTION

Abstract

Clinical symptoms of mild cerebral ischemia, ultrasound composition and blood flow of the brain in 27 mature newborns with intrauterine influenza B (the first group) and in 21 (the second group) with antenatal influenza B combined with influenza A(H3N2) were studied. 30 children of 38-40 weeks from mothers with physiological course of pregnancy became the control. It was found out in the 2^nd group 17 children had hyperexcitability, 11 children had morphofunctional immaturity, 10 had respiratory distress-syndrome of a mild degree, 9 had thymomegalia; in the first group the changed data were established, they were in 7 (р_f<0.05), 3 (р_f<0.05), 2 (р_f<0.05) and in 2 (р_f<0.05) newborns, respectively. At neurosonography in 8 children of the 2^nd group, ventriculomegalia of a light degree was diagnosed in 2 children, immaturity of the brain in 10 children, the cyst of proplexus in 9; in the 1^st group such problems were identified in 1 (р_f1<0.05), 2 (р_f1<0.05) and in 2 (р_f1<0.05) patients, respectively. Newborns with cerebral ischemia conditioned by intrauterine mixedvirus infection in comparison with children of the same perinatal pathology at mono-influenza infection had the increase of the vascular resistance in the middle cerebral artery till 0.76±0.01 relative units (in the first group it was 0.70±0.02 relative units, р<0.01), which was caused by hypoxic-toxic damage of neurons, glial cells, conduction tracts and endotheliocytes of brain blood vessels.