PHENOTYPICAL FEATURES OF BRONCHIAL INFLAMMATION IN PATIENTS WITH ASTHMA WITH DIFFERENT TYPES OF AIRWAY RESPONSE TO HYPOSMOLAR AND COLD STIMULI

The aim of the present work is to compare the inflammation phenotypes in patients with asthma depending on the presence of airway hyperresponsiveness to hyposmolar and cold stimuli. In 49 patients the level of asthma control, lung function, airway response to ultrasonically nebulized distilled water inhalation (DWI) and isocapnic hyperventilation with cold air (IHCA), cellular composition of the induced sputum were assessed. To find phenotypical differences in the character of inflammation, the patients were divided into 4 groups: the 1^st group was with airway hyperresponsiveness to both stimuli (osmotic and cold); the 2^nd group was with isolated bronchial hyperresponsiveness to DWI; the 3^rd group was with isolated response to IHCA; the 4^th group was without any response to both triggers. The patients of the 2^nd and the 3^rd groups were found to have a mixed cellular phenotype of inflammation with the domination of neutrophilic component. Eosinophilic-neutrophilic phenotype of inflammation was in the patients of the 1^st group with the concomitant airway response to hyposmolar and cold stimuli. Eosinophilic phenotype of inflammation was typical for the patients of the 4^th group without bronchial hyperresponsiveness to the triggers. The significance of the formation of cytograms of induced sputum and cellular phenotypes of inflammation has been shown as prognostic markers of asthma course and the efficiency of medical therapy

гиперреактивность бронхов, гипоосмолярный и холодовый стимулы, цитограмма, смешанный фенотип воспаления, эозинофильный фенотип воспаления, bronchial hyperresponsiveness, hyposmolar and cold stimuli, cytogram, mixed phenotype of inflammation, eosinophilic phenotype of inflammation

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