NASOPHARYNGEAL CARRIER STATE OF BACTERIAL PATHOGENS AS A CRITERION FOR EVALUATION OF EFFECTIVENESS OF ANTI-PNEUMOCOCCAL VACCINATION

The aim of the research is to present the comparative analysis of nasopharyngeal carrier state of principal bacterial pathogens among children of the risk group and to elucidate the dynamics of development of non-nosocomial pneumonia among population of Khabarovsk region from 2011 through 2014. 20586 people (including 10200 children) were vaccinated using anti-pneumococcal Prevenar-13 vaccine. The comparative analysis of nasopharyngeal microflora of risk group 220 children (frequently ill children and the children from organized collective), who were studied before (2013) and after the flood (2014), is presented. The children from organized collective (62-68 children) were examined 3 times: before vaccination, 8-10 months after vaccination and 1 year after vaccination. The analysis of community-acquired pneumonia morbidity from 2011 to 2014 was performed. As a result of the research, the tendency to have a high level of pathogens among frequently ill children who were affected by the flood was revealed. The children from organized collective had a higher rate of carrier state of pathogens. It was found out that the level of pathogens significantly decreased 8-10 months and one year after vaccination. A long carrier state (during 8-10 and 12 months) of pneumococcus was revealed in the same children from a number of people discharging bacteria (41%). The level of morbidity with community-acquired pneumonia among population affected by the flood decreased by 22% after vaccination.

дети групп риска, микрофлора носоглотки, противопневмококковая вакцинация, заболеваемость внебольничными пневмониями, children of risk group, nasopharyngeal microflora, anti-pneumococcal vaccination, morbidity of non-nosocomial pneumonia

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