Glomerular filtration rate in persons with chronic obstructive pulmonary disease
https://doi.org/10.36604/1998-5029-2020-75-53-59
Abstract
Introduction. Chronic kidney disease (CKD) is a common pathology of non-infectious etiology. However, there are not enough studies on renal dysfunction in chronic obstructive pulmonary disease (COPD).
Aim. To study the functional state of the kidneys in patients with COPD by assessing the glomerular filtration rate (GFR) and identifying factors associated with its change.
Materials and methods. The study included 65 patients (from 45 to 60 years old) with moderate and severe COPD. Research methods included assessing the severity of clinical symptoms, the number of exacerbations which the patients suffered over the previous year, GFR calculation by the level of creatinine (GFRcr) and cystatin C (GFRcys).
Results. The study revealed that 16.9% of patients with COPD had a decrease in GFRcr<60 mL/min / 1.73 m2 for 3 months. It allows to diagnose CKD. Hyperfiltration was statistically more often detected when calculating GFR by cystatin C level than when using serum creatinine. The level of GFRcr was statistically lower in individuals with severe clinical symptoms and amounted to 85.1 [65.9; 103.9] mL/min / 1.73 m2, which was 1.1 times lower than in individuals with low severity symptoms (93.4 [85.6; 119.7] mL/min / 1.73 m2). GFR in patients with COPD is associated with age, body mass index, smoking person index, severity of inflammation, ventilation disorders, clinical symptoms, hypoxia.
Conclusion. Changes in GFR of varying severity were detected in a large number of patients with COPD. Evaluation of GFR by cystatin C level is more preferable for early detection of hyperfiltration. In individuals with severe clinical symptoms, changes in GFR are more significant than in the group with a low severity of symptoms. Based on the obtained data, it seems appropriate to determine GFR for patients with COPD in dynamics for the early detection of signs of renal dysfunction and the development of therapeutic and preventive measures.
About the Authors
A. A. Bakina
Amur State Medical Academy
Russian Federation
Russian Federation
Anastasia A. Bakina - MD, Postgraduate Student of Department of Faculty and Polyclinic Therapy.
95 Gor'kogo Str., Blagoveshchensk, 675000
V. I. Pavlenko
Amur State Medical Academy
Russian Federation
Russian Federation
Valentina I. Pavlenko - MD, PhD, D.Sc. (Med.), Professor of Department of Faculty and Polyclinic Therapy.
95 Gor'kogo Str., Blagoveshchensk, 675000
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Review
For citations:
Bakina A.A., Pavlenko V.I. Glomerular filtration rate in persons with chronic obstructive pulmonary disease. Bulletin Physiology and Pathology of Respiration. 2020;(75):53-59. (In Russ.) https://doi.org/10.36604/1998-5029-2020-75-53-59
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