State of the immune system in women with exacerbation of cytomegalovirus infection in the third trimester of pregnancy
https://doi.org/10.36604/1998-5029-2020-78-110-115
Abstract
Aim. To study the state of the immune system in women with exacerbation of cytomegalovirus infection (CMVI) in the third trimester of pregnancy.
Materials and methods. The study involved 120 women in the third trimester of pregnancy, uncomplicated and complicated by CMVI. The first group was represented by 30 seronegative women with physiological pregnancy, the second − 30 pregnant women with latent CMVI, leading to the development of placental insufficiency, the third − 30 patients with exacerbation of CMVI and placental insufficiency, and the fourth − 30 women with exacerbation of CMVI, initiating the development of placental insufficiency and the threat of miscarriage. The concentration of immunoglobulins (sIgA, IgA, IgG and IgM) and circulating immune complexes (CIC) in blood serum was studied.
Results. It was shown that in women of the first group the concentration of sIgA in the blood serum was 5.0 (4.10-7.10) mg/ml, IgA − 2.32 (2.09-2.48) mg/ml, IgG – 13.8 (13.0-14.4) mg/ml, IgM − 1.08 (0.98-1.19) mg/ml and CIC − 0.097 (0.076-0.113) AU. In the second group, compared with the first one, the IgG concentration increased to 14.3 (13.3- 15.3) mg/ml (p=0.0284), at the same time there were no statistically significant changes in the sIgA level (p=0.697), IgA (p=0.085), IgM (p=0.197) and CIC (p=0.476). In the third group, in contrast to the second one, an increase in IgG concentration was recorded by 1.09 times (p=0.0016), IgM – by 1.88 times (p=0.000001) and CIC – by 1.70 times (p=0.000001) against the background of a 1.24-times decrease in IgA levels (p=0.000001) and no difference in sIgA concentration (p=0.208). In patients of the fourth group, in comparison with the third one, a decrease in the level of sIgA was diagnosed by 1.66 times (p=0.0000089) and IgA − by 1.41 times (p=0.00048) with an increase in IgG by 1.26 times (p=0.000001), IgM − 1.21 times (p=0.0011) and CIC − 1.09 times (p=0.0199).
Conclusion. With exacerbation of CMVI in the third trimester of pregnancy, complicated by placental insufficiency, severe dysimmunoglobulinemia and autoimmune changes in the female body lead to the development of symptoms of the threat of miscarriage.
Materials and methods. The study involved 120 women in the third trimester of pregnancy, uncomplicated and complicated by CMVI. The first group was represented by 30 seronegative women with physiological pregnancy, the second − 30 pregnant women with latent CMVI, leading to the development of placental insufficiency, the third − 30 patients with exacerbation of CMVI and placental insufficiency, and the fourth − 30 women with exacerbation of CMVI, initiating the development of placental insufficiency and the threat of miscarriage. The concentration of immunoglobulins (sIgA, IgA, IgG and IgM) and circulating immune complexes (CIC) in blood serum was studied.
Results. It was shown that in women of the first group the concentration of sIgA in the blood serum was 5.0 (4.10-7.10) mg/ml, IgA − 2.32 (2.09-2.48) mg/ml, IgG – 13.8 (13.0-14.4) mg/ml, IgM − 1.08 (0.98-1.19) mg/ml and CIC − 0.097 (0.076-0.113) AU. In the second group, compared with the first one, the IgG concentration increased to 14.3 (13.3- 15.3) mg/ml (p=0.0284), at the same time there were no statistically significant changes in the sIgA level (p=0.697), IgA (p=0.085), IgM (p=0.197) and CIC (p=0.476). In the third group, in contrast to the second one, an increase in IgG concentration was recorded by 1.09 times (p=0.0016), IgM – by 1.88 times (p=0.000001) and CIC – by 1.70 times (p=0.000001) against the background of a 1.24-times decrease in IgA levels (p=0.000001) and no difference in sIgA concentration (p=0.208). In patients of the fourth group, in comparison with the third one, a decrease in the level of sIgA was diagnosed by 1.66 times (p=0.0000089) and IgA − by 1.41 times (p=0.00048) with an increase in IgG by 1.26 times (p=0.000001), IgM − 1.21 times (p=0.0011) and CIC − 1.09 times (p=0.0199).
Conclusion. With exacerbation of CMVI in the third trimester of pregnancy, complicated by placental insufficiency, severe dysimmunoglobulinemia and autoimmune changes in the female body lead to the development of symptoms of the threat of miscarriage.
About the Author
I. N. Gorikov
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Igor' N. Gorikov, MD, PhD (Med.), Senior Staff Scientist, Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases
22 Kalinina Str., Blagoveshchensk, 675000
References
1. Bodiyenkova G.M., Kolesnikova L.I. The state of immunological reactivity of the body of pregnant women and their newborns living in the Baikal region. Rossiyskiy vestnik perinatologii i pediatrii 2004; 49(3):55–57 (in Russian).
2. Klimovich V.B., Samoilovich M.P. Immunoglobulin A (Ig A) and its receptors. Medical Immunology (Russia) 2006; 8(4):483–500 (in Russian). https://doi.org/10.15789/1563-0625-2006-4-483-500
3. Solovieva A.S., Lutcenko M.T. Local immunity description at the palatine tonsil surface in herpes virus infected pregnant women. Dal’nevostochnyy meditsinskiy zhurnal 2007; 3:22–23 (in Russian).
4. Pluzhnikova T.A., Mikhnina Е.А., Davydova N.I., Shogiradze L.D. Experience with intravenous immunoglobulin treatment in pregnant women with miscarriage and chronic endometritis. Journal of Obstetrics and Women’s Diseases 2018; 67(5):21–31 (in Russian). doi: 10.17816/JOWD67521-31
5. Solovieva A.S., Lutcenko M.T. Circulating immune complexes in pregnant woman under herpes virus infection. Dal’nevostochnyy meditsinskiy zhurnal 2008; 1:54–56 (in Russian).
6. Zubzhitskaya L.B., Kosheleva N.G., Shapovalova E.A., Arzhanova O.N., Dymarskaya Y.R., Lavrova O.V., Semenova T.V., Stolpner E.G. Status of placental barrier of women at the influence of exogenous and endogenous factors. Zhurnal akusherstva i zhenskikh bolezney = Journal of Obstetrics and Women’s Diseases 2015; 64(5): 36–47 (in Russian). doi: 10.17816/JOWD64536-47
7. Makarov O.V., Ozolinya L.A., Sumedi T.N. Immunological changes in patients with miscarriage of infectious genesis in the first trimester. Rossiyskiy vestnik akushera-ginekologa = Russian Bulletin of Obstetrician-Gynecologist 2008; 8(6):28–32 (in Russian).
8. Shapovalova E.A., Zubzhitskaya L.B., Lavrova O.V., Arzhanova O.N., Dymarskaya Yu.R. Features of a course of pregnancy at bronchial asthma and influence of immunological deposits on a placentary barrier. Zhurnal akusherstva i zhenskikh bolezney = Journal of Obstetrics and Women’s Diseases 2015; 64(2):69–75 (in Russian).
9. Digeon M., Laver M., Riza J., Bach J.F. Detection of circulation immune complexes in human sera by simplified assays with polyethylene glycol. J. Immunol. Methods 1977; 16(2):165–183. doi: 10.1016/0022-1759(77)90051-5
10. Dolgikh V.T. The basics of immunopathology. Nizhniy Novgorod: NGMA; 1998 (in Russian).
11. Drannik G.N. Clinical Immunology and Allergology. Moscow; 2003 (in Russian).
12. Dolgushina N.V., Makatsariya A.D. Viral infections in pregnant women. Moscow: Тriada-Х, 2004 (in Russian).
13. Lutsenko M.T. Dynamics of cortisol activity in peripheral blood of pregnant women who suffered herpes-virus infection. Bûlleten' fiziologii i patologii dyhaniâ = Bulletin Physiology and Pathology of Respiration 2010; (38):51–54 (in Russian).
14. Khaustova S.A., Shkurnikov M.U., Tonevitsky A.G. Short highly intense exercise causes changes in salivary concentrations of hydrocortisone and secretory IgA. Bull. Exp. Biol. Med. 2010; 149(5):635–639. doi: 10.1007/s10517-010-1012-2
15. Alimbarova L.M., Sokha L.G., Baleva L.S., Lavrukhina L.A., Barinskii I.F. Evaluation of the immune and interferon statuses of children infected with herpes simplex virus, living in areas with increased radiation background. Vopr. Virusol. 1997; 42(1):36–41 (in Russian).
Review
For citations:
Gorikov I.N. State of the immune system in women with exacerbation of cytomegalovirus infection in the third trimester of pregnancy. Bulletin Physiology and Pathology of Respiration. 2020;(78):110-115. (In Russ.) https://doi.org/10.36604/1998-5029-2020-78-110-115
Views:
270
Email this article 