Clinical and immunological features of new coronaviral infection SARS-COV-2 in pregnant women (review)

K. S. Lyazgiyan

doi:10.36604/1998-5029-2021-80-91-99

Clinical and immunological features of new coronaviral infection SARS-COV-2 in pregnant women (review)

K. S. Lyazgiyan

https://doi.org/10.36604/1998-5029-2021-80-91-99

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Abstract

The article provides a brief review of the PubMed and Google Scholar databases on the clinical and immunological features of the course of the COVID-19 in pregnant women caused by SARS-CoV-2. The significance of physiological changes in the body of a pregnant woman, namely, an increase in the metabolic rate and oxygen consumption, a decrease in the functional residual capacity, in the adaptability of the immune response in pregnant women to infection is shown. The factors are described that allow pregnant women to be included in the risk group for the development of a COVID-19, such as a decrease in the immune response due to a semi-allogeneic fetus, preeclampsia, as well as a cytokine storm during the pro-inflammatory period of pregnancy. The analysis of the world literature data concerning the clinical and immunological features of the new coronavirus infection in pregnant women made it possible to conclude that the issue of developing an effective method for modulating the immune response by the body of a pregnant woman is insufficiently studied.

Keywords

SARS-CoV-2, COVID-19, pregnancy, clinical and immunological features

References

1. Adamyan L.V., Aznaurova Ya.B., Filippov O.S. COVID-19 and women's health (literature review). Problemy Reproduktsii (Russian Journal of Human Reproduction) 2020; 26(2):6-17 (in Russian). https://doi.org/10.17116/repro2020260216

2. Gorenkov D.V., Khantimirova L.M., Shevtsov V.A., Rukavishnikov A.V., Merkulov V.A., Olefir Yu.V. An Outbreak of a New Infectious Disease COVID-19: β-coronaviruses as a Threat to Global Healthcare. BIOpreparations. Prevention, Diagnosis, Treatment 2020; 20(1):6-20 (in Russian). https://doi.org/doi.org/10.30895/2221-996X-2020-20-1-6-20

3. Kwon J.Y., Romero R., Mor G. (2014) New insights into the relationship between viral infection and pregnancy complications. Am. J. Reprod. Immunol 71(5):387-390. https://doi.org/10.1111/aji.12243

4. Lokken E.M., Huebner E.M, Taylor G.G., Hendrickson S., Vanderhoeven J., Kachikis A., Coler B., Walker C.L., Sheng J.S., Al-Haddad B.J.S., McCartney S.A., Kretzer N.M, Resnick R., Barnhart N., Schulte V., Bergam B., Ma K.K., Albright C., Larios V., Kelley L., Larios V., Emhoff S., Rah J., Retzlaff K., Thomas C., Paek B.W., Hsu R.J., Erickson A., Chang A., Mitchell T., Hwang J.K., Erickson S., Delaney S., Archabald K., Kline C.R., LaCourse S.M., Adams Waldorf K.M.; Washington State COVID-19 in Pregnancy Collaborative. Disease severity, pregnancy outcomes, and maternal deaths among pregnant patients with severe acute respiratory syndrome coronavirus 2 infection in Washington State. Am. J. Obstet. Gynecol. 2021; S0002-9378(21)00033-8. https://doi.org/10.1016/j.ajog.2020.12.1221

5. Marx G.F., Murthy P.K., Orkin L.R. Static compliance before and after vaginal delivery. Br. J. Anaesth. 1970; 42(12):1100-1104. https://doi.org/10.1093/bja/42.12.1100

6. Bayliss DA, Millhorn DE. Central neural mechanisms of progesterone action: application to the respiratory system. J. Appl. Physiol. 1992; 73(2):393-404. https://doi.org/10.1152/jappl.1992.73.2.393

7. Field SK, Bell SG, Cenaiko DF, Whitelaw WA. Relationship between inspiratory effort and breathlessness in pregnancy. J. Appl. Physiol. 1991; 71(5):1897-1902. https://doi.org/10.1152/jappl.1991.71.5.1897

8. Bende M, Gredmark T. Nasal stuffiness during pregnancy. Laryngoscope 1999; 109 (7 Pt 1):1108-1110. https://doi.org/10.1097/00005537-199907000-00018

9. Kourtis A.P., Read J.S., Jamieson D.J. Pregnancy and infection. N. Engl. J. Med. 2014; 370(23):2211-2218. https://doi.org/10.1056/NEJMra1213566

10. Pieper P.G, Hoendermis E.S. Pregnancy in women with pulmonary hypertension. Neth. Heart J. 2011. 19(12):504- 508. https://doi.org/10.1007/s12471-011-0219-9

11. Hegewald M.J., Crapo R.O. Respiratory physiology in pregnancy. Clin. Chest Med. 2011; 32(1):1-13. https://doi.org/10.1016/j.ccm.2010.11.001

12. Mor G., Aldo P., Alvero A.B. The unique immunological and microbial aspects of pregnancy. Nat. Rev. Immunol. 2017;17(8):469-482. https://doi.org/10.1038/nri.2017.64

13. Nelson D.M., Main E., Crafford W., Ahumada G.G. Peripartum heart failure due to primary pulmonary hypertension. Obstet. Gynecol. 1983; 62(3 Suppl):58s-63s.

14. Mehta P., McAuley D.F., Brown M., Sanchez E., Tattersall R.S., Manson J.J. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 2020; 395(10229):1033-1034. https://doi.org/10.1016/S0140-6736(20)30628-0

15. Lam C.M., Wong S.F., Leung T.N., Chow K.M., Yu W.C., Wong T.Y., Lai S.T., Ho L.C. A case-controlled study comparing clinical course and outcomes of pregnant and non-pregnant women with severe acute respiratory syndrome. BJOG 2004; 111(8):771-774. https://doi.org/10.1111/j.1471-0528.2004.00199.x

16. Lapinsky S.E. Acute respiratory failure in pregnancy. Obstet. Med. 2015; 8(3):126-132. https://doi.org/10.1177/1753495X15589223

17. Behzad S., Aghaghazvini L., Radmard A.R., Gholamrezanezhad A. Extrapulmonary manifestations of COVID19: Radiologic and clinical overview. Clin. Imaging. 2020; 66:35-41. https://doi.org/10.1016/j.clinimag.2020.05.013

18. Lippi G., Plebani M. Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis. Clin. Chim. Acta 2020; 505:190-191. https://doi.org/10.1016/j.cca.2020.03.004

19. Kline J.A., Williams G.W., Hernandez-Nino J. D-dimer concentrations in normal pregnancy: new diagnostic thresholds are needed. Clin. Chem. 2005; 51(5):825-829. https://doi.org/10.1373/clinchem.2004.044883

20. Frater J.L., Zini G., d'Onofrio G., Rogers H.J. COVID-19 and the clinical hematology laboratory. Int. J. Lab. Hematol. 2020; 42 (Suppl. 1):11-18. https://doi.org/10.1111/ijlh.13229

21. Wei L., Gao X., Chen S., Zeng W., Wu J., Lin X., Zhang H., Mwamaka Sharifu L., Chen L., Feng L., Wang S. Clinical Characteristics and Outcomes of Childbearing-Age Women With COVID-19 in Wuhan: Retrospective, SingleCenter Study. J. Med. Internet Res. 2020; 22(8):e19642. https://doi.org/10.2196/19642

22. Aghaeepour N., Ganio E.A., Mcilwain D., Tsai A.S., Tingle M., Van Gassen S., Gaudilliere D.K., Baca Q., McNeil L., Okada R., Ghaemi M.S., Furman D., Wong R.J., Winn V.D., Druzin M.L., El-Sayed Y.Y., Quaintance C., Gibbs R., Darmstadt G.L., Shaw G.M., Stevenson D.K., Tibshirani R., Nolan G.P., Lewis D.B., Angst M.S., Gaudilliere B. An immune clock of human pregnancy. Sci. Immunol. 2017; 2(15):eaan2946. https://doi.org/10.1126/sciimmunol.aan2946

23. Rasmussen S.A., Jamieson D.J., Macfarlane K., Cragan J.D., Williams J., Henderson Z. Pandemic Influenza and Pregnancy Working Group. Pandemic influenza and pregnant women: summary of a meeting of experts. Am. J. Public Health 2009; 99 (Suppl 2):S248-254. https://doi.org/10.2105/AJPH.2008.152900

24. Breslin N., Baptiste C., Miller R., Fuchs K., Goffman D., Gyamfi-Bannerman C., D'Alton M. Coronavirus disease 2019 in pregnancy: early lessons. Am. J. Obstet. Gynecol. MFM 2020; 2(2):100111. https://doi.org/10.1016/j.ajogmf.2020.100111

25. Wang Y., Zhang L., Sang L., Ye F., Ruan S., Zhong B., Song T., Alshukairi A.N., Chen R., Zhang Z., Gan M., Zhu A., Huang Y., Luo L., Mok C.K.P., Al Gethamy M.M., Tan H., Li Z., Huang X., Li F., Sun J., Zhang Y., Wen L., Li Y., Chen Z., Zhuang Z., Zhuo J., Chen C., Kuang L., Wang J., Lv H., Jiang Y., Li M., Lin Y., Deng Y., Tang L., Liang J., Huang J., Perlman S., Zhong N., Zhao J., Malik Peiris J.S., Li Y., Zhao J. Kinetics of viral load and antibody response in relation to COVID-19 severity. J. Clin. Invest. 2020; 130(10):5235-5244. https://doi.org/10.1172/JCI138759

26. Suthar M.S., Zimmerman M.G., Kauffman R.C., Mantus G., Linderman S.L., Hudson W.H., Vanderheiden A., Nyhoff L., Davis C.W., Adekunle O., Affer M., Sherman M., Reynolds S., Verkerke H.P., Alter D.N., Guarner J., Bryksin J., Horwath M.C., Arthur C.M., Saakadze N., Smith G.H., Edupuganti S., Scherer E.M., Hellmeister K., Cheng A., Morales J.A., Neish A.S., Stowell S.R., Frank F., Ortlund E., Anderson E.J., Menachery V.D., Rouphael N., Mehta A.K., Stephens D.S., Ahmed R., Roback J.D., Wrammert J. Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients. Cell Rep. Med. 2020; 1(3):100040. https://doi.org/10.1016/j.xcrm.2020.100040

27. Sherer M.L., Lei J., Creisher P., Jang M., Reddy R., Voegtline K., Olson S., Littlefield K., Park H.-S., Ursin R.L., Ganesan A., Boyer T., Brown D.M., Walch S.N., Antar A.A.R., Manabe Y.C., Jones-Beatty K., Golden W.C., Satin A.J., Sheffield J.S., Pekosz A., Klein S.L., Burd I. Dysregulated immunity in SARS-CoV-2 infected pregnant women. medRxiv. Preprint. 2020. https://doi.org/10.1101/2020.11.13.20231373

28. Racicot K., Mor G. Risks associated with viral infections during pregnancy. J. Clin. Invest. 2017; 127(5):1591- 1599. https://doi.org/10.1172/JCI87490

29. Wong S.F., Chow K.M., Leung T.N., Ng W.F., Ng T.K., Shek C.C., Ng P.C., Lam P.W., Ho L.C., To W.W., Lai S.T., Yan W.W., Tan P.Y. Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am. J. Obstet. Gynecol. 2004; 191(1):292-297. https://doi.org/10.1016/j.ajog.2003.11.019

30. Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Zhang L., Fan G., Xu J., Gu X., Cheng Z., Yu T., Xia J., Wei Y., Wu W., Xie X., Yin W., Li H., Liu M., Xiao Y., Gao H., Guo L., Xie J., Wang G., Jiang R., Gao Z., Jin Q., Wang J., Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395(10223):497- 506. https://doi.org/10.1016/S0140-6736(20)30183-5

31. Tetro JA. Is COVID-19 receiving ADE from other coronaviruses? Microbes Infect. 2020; 22(2):72-73. https://doi.org/10.1016/j.micinf.2020.02.006

32. Wu C., Yang W., Wu X., Zhang T., Zhao Y., Ren W., Xia J. Clinical Manifestation and Laboratory Characteristics of SARS-CoV-2 Infection in Pregnant Women. Virol. Sin. 2020; 35(3):305-310. https://doi.org/10.1007/s12250-020-00227-0

33. Kourtis A.P., Read J.S., Jamieson D.J. Pregnancy and infection. N. Engl. J. Med. 2014; 370(23):2211-2218. https://doi.org/10.1056/NEJMra1213566

34. Prompetchara E., Ketloy C., Palaga T. Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pac. J. Allergy Immunol. 2020; 38(1):1-9. https://doi.org/10.12932/AP-200220-0772

35. Di Mascio D., Khalil A., Saccone G., Rizzo G., Buca D., Liberati M., Vecchiet J., Nappi L., Scambia G., Berghella V., D'Antonio F. Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am. J. Obstet. Gynecol. MFM 2020; 2(2):100107. https://doi.org/10.1016/j.ajogmf.2020.100107

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Lyazgiyan K.S. Clinical and immunological features of new coronaviral infection SARS-COV-2 in pregnant women (review). Bulletin Physiology and Pathology of Respiration. 2021;(80):91-99. (In Russ.) https://doi.org/10.36604/1998-5029-2021-80-91-99

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Bulletin Physiology and Pathology of Respiration

Clinical and immunological features of new coronaviral infection SARS-COV-2 in pregnant women (review)

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Clinical and immunological features of new coronaviral infection SARS-COV-2 in pregnant women (review)

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