CHANGES OF THE SYSTEM INFLAMMATORY RESPONSE IN THE SECOND TRIMESTER OF PREGNANCY IN WOMEN WITH EXACERBATION OF CHRONIC SIMPLE BRONCHITIS CAUSED BY INFLUENZA A(H3N2)

There was done an examination of anti- and pro-inflammatory cytokines in the blood serum in 98 women in the second trimester of gestation. The first group included 30 women with physiological course of pregnancy (control). 68 patients with exacerbation of chronic simple bronchitis of influenza etiology were divided and included the second group with 24 patients with antibody titers 1:16-1:64; the third group that had 23 patients with antibody titers 1:32-1:128; the fourth group with 21 women with antibody titers 1:64-1:256. It was found out that pregnant women of the second group in comparison with the first one had the increase of the contents of IL-4 till 27.8±2.31 pg/mL, of TNF-α till 59.3±4.24 pg/mL and of IFN-γ till 55.4±4.16 pg/mL (in the control it was 14.7±1.32 pg/mL, р<0.001; 38.4±3.62 pg/mL, р<0.001 and 32.4±2.03 pg/mL, р<0.001, respectively). At the comparison of values of IL-4 and IFN-γ in the second and third groups there were not revealed any changes of the level of these cytokines, at the same time the concentration of TNF-α grew by 29.7% (р<0.05). The patients of the fourth group in comparison with the third one had the increase of concentration of IL-4 by 12.5% (р<0.05), of TNF-α by 22.8% (р<0.001) and IFN-γ by 17.5% (р<0.05). This suggest an important pathogenetic meaning of the growth of anti-influenza antibodies in the stimulation of the system inflammatory response inducing the development of endothelial pathology and placental insufficiency at the exacerbation of chronic simple bronchitis in women in the second trimester of pregnancy.

pregnancy, chronic bronchitis, influenza А(Н3N2), titers of anti-viral antibodies, cytokines

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