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THE POSSIBLE CORRECTION OF PROCESSES OF LIPID PEROXIDATION OF BIOMEMBRANES INDUCED BY THE COLD EXPOSURE

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Abstract

Modern environmental conditions greatly increased the level of radical forming processes in the body. Cold exposure stimulates the generation of reactive oxygen species inducing peroxidation of lipids as a result of hypoxia development. In experimental conditions the possibility to correct free radical lipid oxidation of rats’ organism membranes was studied with the introduction of nikolizin. The animals were divided into 3 groups and each of them had 40 rats: intact animals which were held in standard conditions of vivarium; the control group in which rats were exposed to cold during three hours daily; the experimental group in which before cooling animals had a daily intake of nikolizin in a dose of 30 mg/kg. It was found out that a daily cold exposure during three hours contributes to the increase of lipid hydroperoxides level (by 18-50%), of diene conjugate (by 33-80%), and of malonic dialdehyde (by 22-37%) against the decrease of antioxidant system activity in the blood of intact animals. The introduction of nikolizin to rats in the conditions of cold exposure contributes to the significant decrease in the blood of lipid hydroperoxides by 14-22%, of diene conjugates by 26-44%, of malonic dialdehyde by 20-25% in comparison with the rats of the control group. While analyzing the effect of nikolizin on the activity of the components of antioxidant system it was shown that the level of ceruloplasmin in the blood of animals was significantly higher by 39-57%, of vitamin E by 22-33%, of catalase by 23-33% in comparison with the same parameters of the rats of the control group. So, the application of nikolizin in the conditions of long cold exposure on the organism of animals under experiment leads to stabilization of the processes of peroxidation against the increase of antioxidant system activity.

For citations:

Dorovskikh V.A., Simonova N.V., Li O.N., Dorovskikh Yu.V. THE POSSIBLE CORRECTION OF PROCESSES OF LIPID PEROXIDATION OF BIOMEMBRANES INDUCED BY THE COLD EXPOSURE. Bulletin Physiology and Pathology of Respiration. 2016;(59):59-63. (In Russ.)

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