THE STATE OF HUMORAL IMMUNITY IN PAIRS “MOTHER-CHILD” AT INFLUENZA A(H3N2) IN THE FIRST TRIMESTER OF PREGNANCY

Abstract

At full-term pregnancy the level of anti-influenza antibodies in 126 pairs “mother-child” at influenza A(H3N2) in the first trimester of gestation was studied. The first group (comparison) was made of 40 pairs “mother-child” at pregnancy not complicated with acute respiratory virus infection, but with exacerbation of somatic diseases as well as moderate and severe somatic and obstetric pathology. The second group consisted of 43 pairs “mother-child” with influenza infection with antibody titer 1:4-1:16; the third group had 41 pairs “mother-child” with influenza А(Н3N2) with antibody titer 1:8-1:32; the fourth group had 42 pairs “mother-child” with influenza infection (antibody titers were 1:32-1:128) associated with the threat of miscarriage at early stages of gestation. It was found out that in the second group in 80% of cases mothers had higher titers of anti-virus antibodies in comparison with the titers of their children; in 12.5% of cases there were equal titers of antibodies in maternal and umbilical blood. In the second and the third groups unlike the first one there was a tendency to the decrease of a number of pairs that had higher titers of antibodies in mothers and there was an increase of pairs with equal titers of anti-virus antibodies. In the fourth group the number of pairs with domination of titers of anti-influenza antibodies increased till 28.6% in children in comparison with the titers in their mothers (in the second group it was in 4.7%, р<0.05), which suggested antenatal infecting of full term newborns.