Comparative analysis of the results of computed tomographic densitovolumetry during the stratification of patients with pulmonary sarcoidosis
https://doi.org/10.36604/1998-5029-2022-85-65-77
Abstract
Aim. To assess the diagnostic significance of the indicators obtained by the new method of quantitative evaluation of digital data of computed tomography (CT) images of the chest (CT densitovolumetry) in groups of patients with a diagnosis of sarcoidosis, stratified by radiological patterns, in comparison with groups formed according to the classification principle of J.G.Scadding , as well as in comparison with functional pulmonary tests.
Materials and methods. Healthy individuals (n=21) and patients with pulmonary sarcoidosis (n=101) were examined. Patients with sarcoidosis were divided into 5 groups according to the J.G.Scadding classification and into 5 groups according to combinations of radiological patterns. The lung function was assessed according to the data of forced expiratory spirometry, body plethysmography, and the study of diffusion capacity and lung volumes. All examined patients underwent a two-stage CT scan of the lungs in the inspiratory and expiratory phases with the measurement of parameters in 3 density ranges.
Results. The values of the obtained quantitative indicators, determined by the new method of CT-densitovolumetry, differed from the control values in healthy individuals both in the general group of patients with sarcoidosis, and in separate groups according to the J.G.Scadding classification and groups divided by radiological patterns. As a result, an intergroup statistically significant difference in indicators was determined. Correlations were found between radiometric measurements and lung function variables.
Conclusion. A new method of CT-densitovolumetry has identified a diagnostic difference between approaches to stratification of patients with pulmonary sarcoidosis. The results obtained can be treated as a useful tool for the development of a unified radiological classification based on qualitative CT characteristics of pathological changes in pulmonary sarcoidosis.
About the Author
E. A. Ignat’eva
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Elena A. Ignat’eva, MD, Postgraduate Student of the Laboratory of Functional Research of Respiratory System, Roentgenologist
22 Kalinina Str., Blagoveshchensk, 675000
References
1. Castro M.D.C., Pereira C.A.C., Soares M.R. Prognostic features of sarcoidosis course in a Brazilian cohort. J. Bras. Pneumol. 2022; 48(1):e20210366. https://doi.org/10.36416/1806-3756/e20210366
2. Statement on sarcoidosis Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am. J. Respir. Crit. Care Med. 1999; 160(2):736–755. https://doi.org/10.1164/ajrccm.160.2.ats4-99
3. Neville E., Walker A.N., James D.G. Prognostic factors predicting the outcome of sarcoidosis an analysis of 818 patients. Q. J. Med. 1983; 52(208):525–533. PMID: 6657915
4. Walsh S.L., Wells A.U., Sverzellati N., Keir G.J., Calandriello L., Antoniou K.M. An integrated clinicoradiological staging system for pulmonary sarcoidosis a case-cohort study. Lancet Respir. Med. 2014; 2(2):123–130. https://doi.org/10.1016/S2213-2600(13)70276
5. Bradley B., Branley H.M., Egan J.J., Greaves M.S., Hansell D.M., Harrison N.K., Hirani N., Hubbard R., Lake F., Millar A.B., Wallace W.A., Wells A.U., Whyte M.K., Wilsher M.L.; British Thoracic Society Interstitial Lung Disease Guideline Group, British Thoracic Society Standards of Care Committee; Thoracic Society of Australia; New Zealand Thoracic Society; Irish Thoracic Society. Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society. Thorax 2008; 63(Suppl. 5):v1–v58. https://doi.org/10.1136/thx.2008.101691
6. Beigelman-Aubry C., Hill C., Guibal A., Savatovsky J., Grenier P.A. Multi-detector row CT and postprocessing techniques in the assessment of diffuse lung disease. Radiographics 2005; 25(6):1639–1652. https://doi.org/10.1148/rg.256055037
7. Hansell D.M., Goldin J.G., King T.E. Jr, Lynch D.A., Richeldi L., Wells A.U. CT staging and monitoring of fibrotic interstitial lung diseases in clinical practice and treatment trials: a position paper from the Fleischner Society. Lancet Respir. Med. 2015; 3(6):483–496. https://doi.org/10.1016/S2213-2600(15)00096-X
8. Gillies R.J., Kinahan P.E., Hricak H. Radiomics: images are more than pictures, they are data. Radiology 2016; 278(2):563–577. https://doi.org/10.1148/radiol.2015151169
9. Scadding J.G. Prognosis of intrathoracic sarcoidosis in England. A review of 136 cases after five years' observation. Br. Med. J. 1961; 2(5261):1165–1172. https://doi.org/10.1136/bmj.2.5261.1165
10. Dhagat P.K., Singh S., Jain M., Singh S.N., Sharma R.K. Thoracic sarcoidosis: imaging with high resolution computed tomography. J. Clin. Diagn. Res. 2017; 11(2): TC15–TC18. https://doi.org/10.7860/JCDR/2017/24165.9459
11. Lenshin A.V., Ignat'eva E.A., Il'in A.V., Perelman J.M. [To the question of reforming the classification of thoracic sarcoidosis]. Bûlleten' fiziologii i patologii dyhaniâ=Bulletin Physiology and Pathology of Respiration 2004; (79): 8–20 (in Russian). https://doi.org/10.36604/1998-5029-2021-79-8-20
12. Vizel A.A., Vizel I.Y. [Sarkoidosis: basic provisions of the project of federal clinical recommendations]. Therapy. 2019; (5): 20–26 (in Russian). https://doi.org/10.18565/therapy.2019.5.20-26
13. Miller M.R., Hankinson J., Brusasco V., Burgos F., Casaburi R., Coates A., Crapo R., Enright P., van der Grinten C.P.M., Gustafsson P., Jensen R., Johnson D.C., MacIntyre N., McKay R., Navajas D., Pedersen O.F., Pellegrino R., Viegi G., Wanger J. Standardisation of spirometry. Eur. Respir. J. 2005; 26:319–338. https://doi.org/10.1183/09031936.05.00034805
14. Coates A.L., Wanger J., Cockcroft D.W., Culver B.H., Kai-Håkon Carlsen, Diamant Z., Gauvreau G., Hall G.L., Hallstrand T.S., Horvath I., de Jongh F.H.C., Joos G., Kaminsky D.A., Laube B.L., Leuppi J.D., Sterk P.J. ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests. Eur. Respir. J. 2017; 49:1601526. https://doi.org/ 10.1183/13993003.01526-2016
15. Hallstrand T.S., Leuppi J.D., Joos G., Hall G.L., Carlsen K.H., Kaminsky D.A., Coates A.L., Cockcroft D.W., Culver B.H., Diamant Z., Gauvreau G.M., Horvath I., de Jongh F.H.C., Laube B.L., Sterk P.J., Wanger J. ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing. Eur. Respir. J. 2018; 52(5):1801033. https://doi.org/10.1183/13993003.01033-2018
16. Ignat’eva E.A., Il’in A.V., Perelman J.M. [Diagnostics of pulmonary sarcoidosis by the method of computed tomographic densitovolumetry]. Bûlleten' fiziologii i patologii dyhaniâ = Bulletin Physiology and Pathology of Respiration 2022; (84):49–62 (in Russian). https://doi.org/10.36604/1998-5029-2022-84-49-62
Review
For citations:
Ignat’eva E.A. Comparative analysis of the results of computed tomographic densitovolumetry during the stratification of patients with pulmonary sarcoidosis. Bulletin Physiology and Pathology of Respiration. 2022;(85):65-77. (In Russ.) https://doi.org/10.36604/1998-5029-2022-85-65-77
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