Prospects for the pharmacological application of N-acyle-thanolamines of polyunsaturated fatty acids in the therapy of respiratory diseases on the example of bronchial asthma
https://doi.org/10.36604/1998-5029-2022-86-129-137
Abstract
Introduction. At present, the mechanisms of the processes of resolving chronic inflammation in asthma are not fully understood. A search for new pharmacological preparations and substances for the treatment and control of the course of asthma is required. Promising in this direction are N-acylethanolamines (NAE) of polyunsaturated fatty acids - bioactive lipid molecules that exhibit many signaling functions. NAEs are capable of influencing the synthesis of pro-inflammatory cytokines and are also appear to be a substrate for the synthesis of pro-permissive lipid signaling molecules. This review collects data on NAE, provides an overview, biosynthesis, and describes their anti-inflammatory effects.
Aim. Summarizing the data of domestic and foreign researchers on the possibility of NAE in the treatment of respiratory diseases on the example of bronchial asthma.
Materials and methods. The review uses data from articles published in PubMed, Google Scholar, eLIBRARY.
Results. The study and compilation of literature on this issue made it possible to conclude that synthetic NAEs are promising pharmacological objects for asthma therapy, however, further testing of the anti-inflammatory effects of NAEs and the establishment of the molecular mechanism of their action on inflammation processes are needed.
About the Authors
I. S. Kovalenko
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration - Research Institute of Medical Climatology and Rehabilitative Treatment
Russian Federation
Russian Federation
Ivan S. Kovalenko, Postgraduate student, Laboratory of Biomedical Research
73g Russkaya Str., Vladivostok, 690105
Yu. К. Denisenko
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration - Research Institute of Medical Climatology and Rehabilitative Treatment
Russian Federation
Russian Federation
Yulia К. Denisenko, PhD, DSc (Biol.), Head of Laboratory of Biomedical Research
73g Russkaya Str., Vladivostok, 690105
T. P. Novgorodtseva
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration - Research Institute of Medical Climatology and Rehabilitative Treatment
Russian Federation
Russian Federation
Tatiana P. Novgorodtseva, PhD, DSc (Biol.), Professor, Deputy Director on Scientific Work, Main Staff Scientist of Laboratory of Biomedical Research
73g Russkaya Str., Vladivostok, 690105
N. V. Bocharova
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration - Research Institute of Medical Climatology and Rehabilitative Treatment
Russian Federation
Russian Federation
Natalia V. Bocharova, PhD (Biol.), Staff Scientist, Laboratory of Biomedical Research
73g Russkaya Str., Vladivostok, 690105
U. M. Omatova
Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration - Research Institute of Medical Climatology and Rehabilitative Treatment
Russian Federation
Russian Federation
Uliana M. Omatova, Junior Staff Scientist, Laboratory of Biomedical Research
73g Russkaya Str., Vladivostok, 690105
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Review
For citations:
Kovalenko I.S., Denisenko Yu.К., Novgorodtseva T.P., Bocharova N.V., Omatova U.M. Prospects for the pharmacological application of N-acyle-thanolamines of polyunsaturated fatty acids in the therapy of respiratory diseases on the example of bronchial asthma. Bulletin Physiology and Pathology of Respiration. 2022;(86):129-137. (In Russ.) https://doi.org/10.36604/1998-5029-2022-86-129-137
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