COMPARATIVE EVALUATION OF DIFFERENT MODIFICATIONS OF METHODS OF RADIATION THERAPY IN PATIENTS WITH CERVICAL CANCER

The aim of the research is to make a comparative evaluation of the results of treatment of cervical cancer in patients who had the radiation therapy with the application of the modes of sequential and parallel methods of bringing the dose to the pathological focus. The results of combined radiation therapy in 120 patients with cervical cancer were analyzed. Depending on the treatment tactics, the patients were divided into 2 groups of 60 patients who underwent a sequential or parallel method of bringing the dose to the lesion and regional metastasis routes, when the total focal dose in both cases matched the optimally required parameters - 80-85 Gr in the primary tumor and points "A" and 60 Gr in points "B". Distance radiation therapy was carried out 5 times a week, followed by a break of 3-5 weeks and a further application of the intracavitary method. In the second case, a daily distance therapy was carried out to a total focal dose of 18 Gr, after which the number of sessions per week decreased to 3 times and in some days (2 times a week) there was done an intracavitary treatment. The following results were obtained: an objective therapeutic effect was observed in 108 (90%) patients. Full tumor regression was recorded in 95 (87.9%), partial - in 12.1%, and failures were detected in 10% of women. During the three-year follow-up period, 20.0% of patients of the first group and 10.9% of the second group showed progression of the disease manifested by recurrence in the irradiation zones, recurrence+metastases and metastases of the primary tumor, usually in the inguinal and paraaortic lymph nodes, pelvic bones, liver, lungs. The median of remission duration in the first group was 20 months with a three-year survival rate of 68.0%, and in the second it was 26 and 82.0%, respectively. Complications in the form of mucous response to radiation exposure, radiation cystitis, proctitis, enterocolitis in the second group of patients were significantly less common than in the first. Thus, for the treatment of patients with cervical cancer, the most effective is the use of combined radiation therapy in parallel irradiation.

cervical cancer, methods of radiation therapy, combined radiation therapy, sequential and parallel regimes of irradiation

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