The effect of TRPV1 gene polymorphism on the development of progressive course of chronic obstructive pulmonary disease
https://doi.org/10.36604/1998-5029-2023-89-36-43
Abstract
Introduction. It is known that the course of chronic obstructive pulmonary disease (COPD) may vary depending on the rate of bronchial obstruction progression. It has been shown that TRPV1 channels play an important role in the formation of some pathological syndromes typical for COPD.
Aim. To study the effect of single nucleotide polymorphisms (SNPs) of TRPV1 gene on the rate of bronchial obstruction progression in COPD patients.
Materials and methods. We examined 103 patients with COPD, including 47 with rapid progression of bronchial obstruction (decrease in FEV1≥50 ml/year). SNPs rs460716, rs222749, rs222747, and rs8065080 were genotyped by LATE-PCR.
Results. We established that rs460716 SNP had a significant effect on the development of progressive bronchial obstruction in COPD. The CC+TT genotypes were more common among patients with progressive disease (48.9% versus 23.2%), while the heterozygous genotype was protective (p=0.006). Differences remained significant after adjusting for sex, age, pack-year index and baseline FEV1 (OR 3.2; 95%CI [1.32; 7.57], p=0.009).
Conclusion. The obtained results indicate a negative influence of the homozygous genotypes carriage for TRPV1 rs460716 SNP on the course of COPD.
About the Authors
D. A. Gassan
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Dina A. Gassan, PhD (Med.), Staff Scientist, Laboratory of Molecular and Translational Research
22 Kalinina Str., Blagoveshchensk, 675000
D. E. Naumov
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Denis E. Naumov, PhD (Med.), Head of Laboratory of Molecular and Translational Research
22 Kalinina Str., Blagoveshchensk, 675000
O. O. Kotova
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Olesya O. Kotova, PhD (Med.), Junior Staff Scientist, Laboratory of Molecular and Translational Research
22 Kalinina Str., Blagoveshchensk, 675000
I. Yu. Sugaylo
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Ivana Yu. Sugaylo, PhD (Med.), Junior Staff Scientist, Laboratory of Molecular and Translational Research
22 Kalinina Str., Blagoveshchensk, 675000
E. G. Sheludko
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Elizaveta G. Sheludko, PhD (Med.), Staff Scientist, Laboratory of Molecular and Translational Research
22 Kalinina Str., Blagoveshchensk, 675000
E. Yu. Afanas’eva
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Evgeniya Yu. Afanas’eva, PhD (Med.), Junior Staff Scientist, Laboratory of Molecular and Translational Research
22 Kalinina Str., Blagoveshchensk, 675000
Y. G. Gorchakova
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Yana G. Gorchakova, Research Laboratory Assistant, Laboratory of Molecular and Translational Research
22 Kalinina Str., Blagoveshchensk, 675000
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Review
For citations:
Gassan D.A., Naumov D.E., Kotova O.O., Sugaylo I.Yu., Sheludko E.G., Afanas’eva E.Yu., Gorchakova Y.G. The effect of TRPV1 gene polymorphism on the development of progressive course of chronic obstructive pulmonary disease. Bulletin Physiology and Pathology of Respiration. 2023;(89):36-43. (In Russ.) https://doi.org/10.36604/1998-5029-2023-89-36-43
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