EFFECTS OF LOW TEMPERATURES ON AIRWAY EPITHELIUM AND REACTION OF LIPID PEROXIDATION IN THE LUNGS OF RATS OF DIFFERENT AGES
https://doi.org/10.12737/article_58e44a39659809.58028076
Abstract
The aim of the research is to estimate the changes in the process of regeneration of airway epithelial lining of rats of different age under general cooling of the body. The research was done on 60 white outbread mice at the age of 6-7 months (young) and 19-20 months (old). Each group included 2 subgroups: the first one had intact animals; the second one consisted of animals which were subject to general cooling during 14 days by 3 hours daily at the temperature of -15ºС. Cranial and caudal parts of trachea mucosa and the wall of intralobular bronchus (of a small calibre) were the object of the research. It was found out that with the general cooling of the body in the epithelium of the cranial and caudal trachea in old animals compared with young rats there was indicated a significant reduction in the number of basal and especially intermediate cells, and the increase in the number of goblet ones. The increase in the number of epithelial cells, primarily of intermediate ones in the state of extrusion, was found out. In small bronchi in old rats the number of ciliated cells decrease whereas their destructive changes increase and the number of Clara cells in the elimination of the state grow. The effect of low temperatures leads to the activation of lipid peroxidation reactions against the decrease of the contents of vitamin E in the lungs of rats, especially the older animals.
About the Authors
V. S. Namakonova
Amur State Medical Academy
Russian Federation
Russian Federation
N. P. Krasavina
Amur State Medical Academy
Russian Federation
Russian Federation
S. S. Tseluyko
Amur State Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Namakonova V.S., Krasavina N.P., Tseluyko S.S. EFFECTS OF LOW TEMPERATURES ON AIRWAY EPITHELIUM AND REACTION OF LIPID PEROXIDATION IN THE LUNGS OF RATS OF DIFFERENT AGES. Bulletin Physiology and Pathology of Respiration. 2017;(63):61-65. (In Russ.) https://doi.org/10.12737/article_58e44a39659809.58028076
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