Cardiorespiratory predictors of decreased neurodynamic performance in young adults residing in a Northern region

Introduction. Preserving the working population in strategically important northern territories is a key national priority.

Aim. To identify cardiorespiratory predictors that influence the decline in neurodynamic indicators of work capacity among young individuals permanently living in a Northern region.

Materials and methods. The study included 123 individuals aged 18–45 years, permanently residing in the oil- and gas-producing northern region of KhantyMansiysk Autonomous Okrug–Yugra in Russia. Exclusion criteria were shift workers, acute respiratory infections (ARI) at the time of examination, and any chronic diseases. Participants were divided into two groups: 90 individuals who experienced ARI fewer than four times a year and 33 individuals who experienced ARI four or more times a year. Neurodynamic, hemodynamic, and spirometric parameters, inflammation markers, and cardiorespiratory predictors of reduced neurodynamic performance were assessed.

Results. Decreased neurodynamic performance was detected in 36.4% of frequently ill participants versus 17.8% of infrequently ill participants. Compared to the group of infrequently ill persons, the group of frequently ill persons had longer residence in the northern region, lower forced expiratory volume in 1 second (FEV₁), higher systolic and diastolic blood pressure (SBP, DBP), increased central systolic aortic pressure (cSAP), and a higher LF/HF ratio in heart rate variability due to reduced high-frequency (HF) power. In addition, the group of frequently ill persons exhibited elevated lymphocyte counts and high-sensitivity C-reactive protein (hs-CRP). Inter-system associations were found among neurodynamic indices, respiratory function, hemodynamics, heart rate variability, and inflammatory activity.

Conclusion. Cardiorespiratory predictors of decreased neurodynamic performance in young adults permanently residing in a northern region include a tendency toward reduced FEV₁, elevated SBP and DBP, increased cSAP, and an increased LF/HF ratio in heart rate variability. Longer residence in the North and higher hs-CRP levels also play a significant role in the development of cardiorespiratory pathology affecting neurodynamic performance.  

1. [Strategy for the development of the Arctic zone of the Russian Federation and ensuring national security for the period up to 2035] (in Russian). Available at: http://www.scrf.gov.ru/security/economic/Arctic_stratery/

2. [Khanty-Mansiysk Autonomous Okrug –Yugra. Official statistics of the Federal State Statistics Service for Tyumen Oblast, Khanty-Mansiysk Autonomous Okrug – Yugra and Yamalo-Nenets Autonomous Okrug] (in Russian). Available at: https://72.rosstat.gov.ru/ofstat_xmao

3. Shurkevich N.P. Vetoshkin A.S., Simonyan A.A., Gapon L.I., Kareva M.A. [Hypertension in individuals working in the Arctic on a rotating basis: relationship of arterial stiffness with inflammatory markers and some metabolic risk factors]. Rossijskiy kardiologicheskiy zhurnal = Russian Journal of Cardiology 2023; 28(4):69–78 (in Russian). https://doi.org/10.15829/1560-4071-2023-5167

4. Vetoshkin A.S., Shurkevich N.P., Simonyan A.A., Gapon L.I., Kareva M.A., Semerikova A.M. [Arterial hypertension in the Arctic: the role of stress and autonomic dysfunction, gender differences]. Sibirskiy zhurnal klinicheskoy i eksperimental'noy meditsiny = The Siberian Journal of Clinical and Experimental Medicine 2024; 3 (1):83–93 (in Russian). https://doi.org/10.29001/2073-8552-2024-39-1-83-93

5. Karpov R.S., Dudko V.A., Klyashev S.M. [Heart - Lungs: pathogenesis, clinic, functional diagnostics and treatment of combined forms of IBS and chronic obstructive pulmonary diseases]. Tomsk: izdatel'stvo STT; 2004 (in Russian).

6. Dolgopolova D.A., Popova M.A., Terentyeva N.N. [Forecasting coronary events based on the analysis of the dynamics of morphofunctional parameters of the cardiovascular system in patients with chronic obstructive pulmonary disease in the North]. Arkhiv vnutrenney meditsiny = The Russian Archives of Internal Medicine 2018; 8(1):36–44 (in Russian). https://doi.org/10.20514/2226-6704-2018-8-1-36-44

7. Kobalava Zh.D., Konradi A.O., Nedogoda S.V., Arutyunov G.P., Baranova E.I., Barbarash O.L., Villevalde S.V., Galyavich A.S., Glezer M.G., Drapkina O.M., Kotovskaya Yu.V., Libis R.A., Lopatin Yu.M., Nedoshivin A.O., Ostroumova O.D., Ratova L.G., Tkacheva O.N., Chazova I.E., Chesnikova A.I., Chumakova G.A. [Russian Society of Cardiology position paper on 2018 Guidelines of the European Society of Cardiology/European Society of Arterial Hypertension for the management of arterial hypertension]. Rossiyskiy kardiologicheskiy zhurnal= Russian journal of cardiology 2018; 23(12):131–142 (in Russian). https://doi.org/10.15829/1560-4071-2018-12-131-142

8. Drobyshev V.A., Shpagina L.A., Abramovich S.G., Agasarov L.G. [Dynamic study of risk factors for cardiorespiratory diseases in men with high normal blood pressure in a health center]. Ateroskleroz = Atherosclerosis 2023; 19(3):214–215 (in Russian). https://doi.org/10.52727/2078-256X-2023-19-3-214-215

9. Albasri A., OʼSullivan J.W., Roberts N.W., Prinjha S., McManus R.J., Sheppard J.P. A comparison of blood pressure in community pharmacies with ambulatory, home and general practitioner office readings: systematic review and metaanalysis. J. Hypertens. 2017; 35(10):1919–1928. https://doi.org/10.1097/HJH.0000000000001443

10. Ishmurzin G.P., Serebryakova O.A., Suzev K.N., Dolganova D.A., Gainullina A.H. [Cardiovascular complications of respiratory viral infections]. Sibirskiy zhurnal klinicheskoy i eksperimentalnoy meditsyny` = The Siberian Journal of Clinical and Experimental Medicine 2023; 37(4):31–37 (in Russian). https://doi.org/10.29001/2073-8552-2022-37-4-31-37

11. Savushkina O.I., Kulagina I.Ts., Malashenko M.M., Kuzmina E.R., Chushkin M.I., Kryukov E.V. [Long-term consequences of the functional state of the respiratory system after SARS-CoV-2-associated lung damage]. Bûlleten' fiziologii i patologii dyhaniâ = Bulletin Physiology and Pathology of Respiration 2024; 93:48–59 (in Russian). https://doi.org/10.36604/1998-5029-2024-93-48-59

12. Popova M.A., Chistova V.V., Scherbakova А.E. [Indicators of pulse, central and peripheral blood pressure of northern university teachers who underwent COVID-19 while working remotely]. Siberian Journal of Life Sciences and Agriculture 2021; 13(4):175–192 (in Russian). https://doi.org/10.12731/2658-6649-2021-13-4-175-192

13. Shulga A.S., Andrievskaya I.A., Menshikova I.G., Zabolotskikh T.V. [Analysis of laboratory and instrumental data in young patients with COVID-19 and cardiovascular disorders]. Bûlleten' fiziologii i patologii dyhaniâ = Bulletin Physiology and Pathology of Respiration 2024; 93:60–71 (in Russian). https://doi.org/10.36604/1998-5029-2024-93-60-71

14. Kollias A., Ntineri A., Stergiou G.S. Association of night-time home blood pressure with night-time ambulatory blood pressure and target-organ damage: a systematic review and meta-analysis. J. Hypertension 2017; 35(3):442–452. https://doi.org/10.1097/HJH.0000000000001189

15. Denegri B., Boriani G. High sensitivity C-reactive protein (hsCRP) and its implications in cardiovascular outcomes. Cur. Pharm. Des. 2021; 7(2):261–275. https://doi.org/10.2174/1381612826666200717090334

16. [Apparatus for measuring central aortic and peripheral blood pressure] (in Russian). Available at: https://diapark.ru/a-pulse_caspa.html

17. Kotovskaya Yu.V., Kobalava Zh.D. [Central pressure in clinical practice: current state of the problem]. Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular Therapy and Prevention 2009; 8(4):8–13 (in Russian).

18. Kuznetsov A.A., Tsvetkova E.E., Denisova D.V., Ragino Yu.I., Voevoda M.I. [Central aortic pressure: reference and diagnostic values]. Kardiologiya = Cardiology 2019; 59(3):11–17 (in Russian). https://doi.org/10.18087/cardio.2019.3.10235

19. [Poli-Spectrum.NET Quick Start Guide: RBS031.01.001.000 (29.06.2018)]. Ivanovo: «Neurosoft», 2018 (in Russian).

20. Mikhaylov V.M. [Variability of rhythm of the heart (a new look at the old paradigm)]. Ivanovo: «Neurosoft», 2017 (in Russian). ISBN: 978-5-9909171-0-1.

21. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task force of the European society of cardiology and the north American society of pacing and electrophysiology. Circulation 1996; 93(5):1043–1065. PMID: 8598068.

22. [Spiro-Spektr’ User Manual: Spirometer for Diagnostics of Lung Ventilation Capacity.RE019.01.009.002 (13.01.2021)]. Ivanovo: Neurosoft, 2021 (in Russian).

23. [Methodical recommendations. Spirometry]. Moskow: Russian Respiratory Society; 2023 (in Russian). Available at: https://spulmo.ru/upload/kr/Spirometria_2023.pdf?t=1

24. [Quick start guide «NS-Psychotest.NET»: software: RBS010.02.003.000 (19.11.2019)]. Ivanovo: «Neurosoft», 2019 (in Russian).

25. Loskutova T.D. [Reaction time as a psychophysiological method of assessing the functional state of the CNS. In: Zimkina A.M., Klimova-Cherkasova V.I., editors. Neurophysiological studies in the expertise of working capacity]. Leningrad: Meditsina, Leningradskoye otdeleniye; 1978:165–194 (in Russian).

26. Mantrova I.N. [Methodical guide on psychophysiological and psychological diagnostics: NSFT 010999.001 MU]. Ivanovo: «Neurosoft Ltd.», 2007 (in Russian).

27. Radchenko S.G. [Methodology of regression analysis]. Kiyev: «Korniychuk»; 2011 (in Russian). ISBN: 978-9667599-72-0.