A case report of primary cardiac lymphoma
https://doi.org/10.36604/1998-5029-2025-95-116-125
Abstract
Introduction. Primary cardiac lymphoma is an extremely rare malignant neoplasm. Diagnosis is often delayed because clinical manifestations are nonspecific and, in most cases, appear only at the terminal stage of the disease.
Aim. To present a clinical case of primary cardiac lymphoma.
Materials and methods. A concise literature review of cardiac lymphomas is provided, followed by a clinical case from the authors’ practice.
Results. The disease had a prolonged course, initially masquerading as ischemic heart disease. Due to arrhythmias, the patient underwent a cardiac ultrasound examination, which first revealed a tumor in the right heart chambers. During surgery, a tumor of the right ventricle infiltrating the right atrium was confirmed; however, given the extent of the lesion, the case was deemed incurable. Histological and immunohistochemical (IHC) analyses established the diagnosis of diffuse large B-cell lymphoma of the heart, which was subsequently confirmed on autopsy.
Conclusion. In this scenario, primary cardiac lymphoma mimicked ischemic heart disease and arrhythmias. Echocardiography in such patients allows for early suspicion of a cardiac tumor. A definitive diagnosis can only be made following histological and immunohistochemical examination of biopsy or surgical material.
About the Authors
A. A. Grigorenko
Amur Regional Oncological Dispensary; Amur State Medical Academy
Russian Federation
Russian Federation
Aleksey A. Grigorenko, MD, PhD, DSc (Med.), Professor, Head of Department Pathological Anatomy; Professor of Department of Pathological Anatomy with Forensic Medicine Course
110 Oktyabrʹskaya Str., Blagoveshchensk, 675000
95 Gor'kogo Str., Blagoveshchensk, 675000
T. V. Sycheva
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Tatyana V. Sycheva, Ultrasonographer, Postgraduate Student, Laboratory of Functional Research of Respiratory System
22 Kalinina Str., Blagoveshchensk, 675000
V. V. Voytsekhovskiy
Amur State Medical Academy
Russian Federation
Russian Federation
Valeriy V. Voytsekhovskiy, MD, PhD, DSc (Med.), Professor, Head of Department of Hospital Therapy with Pharmacology Course
95 Gor'kogo Str., Blagoveshchensk, 675000
S. N. Roshchin
Amur Regional Oncological Dispensary
Russian Federation
Russian Federation
Sergey N. Roshchin, MD, PhD (Med.), Pathologist, Department of Pathological Anatomy
110 Oktyabrʹskaya Str., Blagoveshchensk, 675000
A. A. Mazurenko
Amur Regional Clinical Hospital
Russian Federation
Russian Federation
Artem A. Mazurenko, MD, PhD (Med.), Head of Department of Vascular Surgery
26 Voronkova Str., Blagoveshchensk, 675028
А. O. Gerasimenko
Amur Regional Clinical Hospital
Russian Federation
Russian Federation
Anton O. Gerasimenko, MD, Physician, Department of Vascular Surgery
26 Voronkova Str., Blagoveshchensk, 675028
N. B. Golov
Amur Regional Clinical Hospital
Russian Federation
Russian Federation
Nikita B. Golov, MD, Physician, Department of Vascular Surgery
26 Voronkova Str., Blagoveshchensk, 675028
M. S. Kuz'mina
Amur Regional Clinical Hospital
Russian Federation
Russian Federation
Mariya S. Kuz'mina, MD, Physician, Department of Vascular Surgery
26 Voronkova Str., Blagoveshchensk, 675028
V. V. Musorin
Amur Regional Clinical Hospital
Russian Federation
Russian Federation
Vladimir V. Musorin, MD, Pathologist, Department of Pathological Anatomy
26 Voronkova Str., Blagoveshchensk, 675028
I. N. Vinokhodova
Amur Regional Oncological Dispensary
Russian Federation
Russian Federation
Irina N. Vinokhodova, MD, PhD (Med.), Ultrasonographer
110 Oktyabrʹskaya Str., Blagoveshchensk, 675000
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Review
For citations:
Grigorenko A.A., Sycheva T.V., Voytsekhovskiy V.V., Roshchin S.N., Mazurenko A.A., Gerasimenko А.O., Golov N.B., Kuz'mina M.S., Musorin V.V., Vinokhodova I.N. A case report of primary cardiac lymphoma. Bulletin Physiology and Pathology of Respiration. 2025;(95):116-125. (In Russ.) https://doi.org/10.36604/1998-5029-2025-95-116-125
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