Assessment of phospholipid content in blood leukocytes of parturient women who had COVID-19 during the third trimester of pregnancy
https://doi.org/10.36604/1998-5029-2025-98-139-143
Abstract
Aim. To assess the content of phospholipids in leukocytes of peripheral blood in parturient women who had COVID-19 during the third trimester of pregnancy.
Materials and methods. The amount of the cytochemical reaction product for phospholipids in leukocytes of peripheral blood was determined using the reagent kit "DIAHIM-CYTOSTEINSCh" (Russia) in 102 parturient women. The first group included patients with mild course of COVID-19 (n = 34), the second group — patients with moderate course of COVID-19 (n = 32). The control group consisted of 36 women not infected with SARS-CoV-2.
Results. The phospholipid content in leukocytes of pregnant women who had COVID-19 differed significantly compared to the control group. In the control group, the mean cytochemical coefficient (MCC) was 2.67 ± 0.05 arbitrary units. In patients with COVID-19, a significant decrease in MCC was observed: in persons with a mild course of the disease to 2.42 ± 0.05 (p < 0.001), and in persons with a moderate course to 1.98 ± 0.04 arbitrary units (p < 0.001).
Conclusion. The data obtained suggest that COVID-19 infection affects the phospholipid content in the leukocytes of parturient women, reducing their amount. Further investigation of this issue may provide a detailed explanation of the impact of COVID-19 infection on pregnancy course and perinatal outcomes.
About the Authors
O. L. Kutepova
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Olʹga L. Kutepova, PhD (Biol.), Staff Scientist, Laboratory of Molecular and Translational Research
22 Kalinina Str., Blagoveshchensk, 675000
I. A. Andrievskaya
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Irina A. Andrievskaya, PhD, DSc (Biol.), Professor of RAS, Head of Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases
22 Kalinina Str., Blagoveshchensk, 675000
I. V. Dovzhikova
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
Inna V. Dovzhikova, PhD, DSc. (Biol.), Leading Staff Scientist of Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases
22 Kalinina Str., Blagoveshchensk, 675000
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Review
For citations:
Kutepova O.L., Andrievskaya I.A., Dovzhikova I.V. Assessment of phospholipid content in blood leukocytes of parturient women who had COVID-19 during the third trimester of pregnancy. Bulletin Physiology and Pathology of Respiration. 2025;(98):139-143. (In Russ.) https://doi.org/10.36604/1998-5029-2025-98-139-143
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