Preview

Bulletin Physiology and Pathology of Respiration

Advanced search

ROLE OF MESENCHYMAL STEM CELLS IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (REVIEW)

https://doi.org/10.12737/article_5c127a27ba9a85.88292840

Abstract

Current methods of treatment of chronic obstructive pulmonary disease are not effective enough and lead to the progression of the disease and disability of the patient. One of the promising methods of chronic obstructive pulmonary disease therapy is the use of the possibilities of regenerative medicine, in particular, mesenchymal stem cells. The review demonstrates the achievements of research groups developing approaches to chronic obstructive pulmonary disease therapy based on mesenchymal stem cells. Our attention was focused on the problems and possible ways to show the mechanism of action of mesenchymal stem cells. The issues of safety of mesenchymal stem cells application are also discussed.

About the Authors

S. S. Tseluyko
Amur State Medical Academy
Russian Federation


A. A. Yatsenko
Amur State Medical Academy
Russian Federation


D. V. Leonov
Amur State Medical Academy
Russian Federation


E. M. Ustinov
Amur State Medical Academy
Russian Federation


V. A. Kushnarev
Medical Research Center “Next Gen Biosystem"
Russian Federation


References

1. Татаринова О.С., Осипова Е.Ю., Румянцев С. А. Биологические свойства и возможности клинического использования мезенхимальных стволовых клеток // Онкогематология. 2009. Т.4, №4. С.33-44.

2. Пронина Е. Ю. Вершина айсберга: эпидемиология ХОБЛ (обзор литературы) // Вестник современной клинической медицины. 2011. Т.4, №3. С.18-23.

3. Респираторная медицина: Руководство: в 3 т. / под ред. А.Г.Чучалина. М.: Литтерра, 2017. Т. 1. 640 с.

4. Arja C., Surapaneni K.M., Raya P., Adimoolam C., Balisetty B., Kanala K.R. Oxidative stress and antioxidant enzyme activity in South Indian male smokers with chronic obstructive pulmonary disease // Respirology. 2013. Vol.18, №7. Р.1069-1075. doi: 10.1111/resp.12118

5. Armstrong L., Lako M., Buckley N., Lappin T., Murphy M., Nolta J., Pittenger M., Stojkovic M. Editorial: our top 10 developments in stem cell biology over the last 30 years // Stem cells. 2011. Vol.30, №1. Р.2-9. doi: 10.1002/stem.1007

6. Bagdonas E., Raudoniute J., Bruzauskaite I., Aldonyte R. Novel aspects of pathogenesis and regeneration mechanisms in COPD // Int. J. Chron. Obstruct. Pulmon. Dis. 2015. Vol.10. Р.995-1013. doi:10.2147/COPD.S82518

7. Branson R., Johannigman J. Pre-hospital oxygen therapy // Respir. Care. 2012. Vol.58, №.1. Р.86-97. doi: 10.4187/respcare.02251

8. Burney P., Jithoo A., Kato B., Janson C., Mannino D., Nizankowska-Mogilnicka E., Studnicka M., Tan W., Bateman E., Koçabas A., Vollmer W., Gislason T., Marks G., Koul P., Gnatiuc L., Buist S. Chronic obstructive pulmonary disease mortality and prevalence: the associations with smoking and poverty: a BOLD analysis // Thorax. 2014. Vol.69, №5. Р.465-473. doi: 10.1136/thoraxjnl-2013-204460

9. Calió M., Marinho D., Ko G., Ribeiro R., Carbonel A., Oyama L., Ormanji M., Guirao T., Calió P., Reis L., Simões M., Lisbôa-Nascimento T., Ferreira A., Bertoncini C. Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model // Free Radic. Biol. Med. 2014. Vol.70. Р.141-154. doi: 10.1016/j.freeradbiomed.2014.01.024

10. Caplan A. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine // J. Cell. Physiol. 2007. Vol.213, №2. Р.341-347. doi: 10.1002/jcp.21200

11. Chen Y., Lan Y., Chen L., Huang T., Choo K., Cheng W., Lee H., Chong K. Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol alleviates elastase-induced emphysema in a mouse model // Cell Stress Chaperones. 2015. Vol.20, №6. Р.979-989. doi: 10.1007/s12192-015-0627-7

12. Cheng S., Lin C., Yao C. mesenchymal stem cell administration in patients with chronic obstructive pulmonary disease: state of the science // Stem Cells Int. 2017, Vol.1. Р.1-14. doi: 10.1155/2017/8916570

13. Churg A., Wang R., Tai H., Wang X., Xie C., Dai J., Shapiro S., Wright J. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-α release // Am. J. Respir. Crit. Care Med. 2003. Vol.167, №8. Р.1083-1089. doi: 10.1164/rccm.200212-1396OC

14. Cosio M.G., Majo J., Cosio M.G. Inflammation of the airways and lung parenchyma in COPD // Chest. 2002. Vol.121, №5 (Suppl), Р.160S-165S. doi:10.1378/chest.121.5

15. Curley G., Hayes M., Ansari B., Shaw G., Ryan A., Barry F., O'Brien T., O'Toole D., Laffey J. Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat // Thorax. 2011. Vol.67, №6. Р.496-501. doi: 10.1136/thoraxjnl-2011-201059

16. Demedts I., Demoor T., Bracke K., Joos G., Brusselle G. Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema // Respir. Res. 2006. Vol.7, №1. Р.53-63. doi:10.1186/1465-9921-7-53

17. Finkelstein R., Fraser R., Ghezzo H., Cosio M. Alveolar inflammation and its relation to emphysema in smokers // Am. J. Respir. Crit. Care Med. 1995. Vol.152, №5(Pt1). P.1666-1672. doi:10.1164/ajrccm.152.5.7582312

18. Fredenburgh L., Perrella M., Mitsialis S. The role of heme oxygenase-1 in pulmonary disease // Am. J. Respir. Cell. Mol. Biol. 2007. Vol.36, №2. P.158-165. doi: 10.1165/rcmb.2006-0331TR

19. Guan X., Song L., Han F., Cui Z., Chen X., Guo X., Xu W. Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors // J. Cell. Biochem. 2012. Vol.114, №2. P.323-335. doi: 10.1002/jcb.24377

20. Gupta N., Krasnodembskaya A., Kapetanaki M., Mouded M., Tan X., Serikov V., Matthay M. Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia // Thorax. 2012. Vol.67, №6. P.533-539. doi: 10.1136/thoraxjnl-2011-201176

21. Gupta N., Su X., Popov B., Lee J., Serikov V., Matthay M. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice // J. Immunol. 2007. Vol.179, №3. P.1855-1863. doi: 10.4049/jimmunol.179.3.1855

22. Huang K., Wu X.M., Wang X.Y., Kang X.W., Xiao J.L., Li Z.G., Lu P. The effect of marrow mesenchymal stem cell transplantation on pulmonary fibrosis in rats // Zhonghua Jie He He Hu Xi Za Zhi. 2012. Vol.35, №9. P.659-664.

23. Iyer S., Rojas M. Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies // Expert Opin. Biol. Ther. 2008. Vol.8, №5. P.569-581. doi:10.1517/14712598.8.5.569

24. Jin Z., Wang Q., Bi H., Zhou K., He L., He X., Wu Q., Pan X. Effects and possible mechanisms of mesenchymal stem cell transplantation on emphysema in rats // Zhonghua Yi Xue Za Zhi. 2015. Vol.95, №22. P.1731-1735.

25. Kanazawa H., Yoshikawa J. Elevated oxidative stress and reciprocal reduction of vascular endothelial growth factor levels with severity of COPD // Chest. 2005. Vol.128, №5, Р.3191-3197. doi: 10.1378/chest.128.5.3191

26. Katsha A., Ohkouchi S., Xin H., Kanehira M., Sun R., Nukiwa T., Saijo Y. Paracrine factors of multipotent stromal cells ameliorate lung injury in an elastase-induced emphysema model // Mol. Ther. 2011. Vol.19, №1. Р.196-203. doi: 10.1038/mt.2010.192

27. Kim S., Lee J., Kim H., Park M., Huh J., Ro J., Oh Y., Lee S., Lee Y. Mesenchymal stem cell-conditioned media recovers lung fibroblasts from cigarette smoke-induced damage // Am. J. Physiol. Lung Cell. Mol. Physiol. 2012. Vol.302, №9. Р.L891-L908. doi: 10.1152/ajplung.00288.2011

28. Kotton D.N., Ma B.Y., Cardoso W.V., Sanderson E.A., Summer R.S., Williams M.C., Fine A. Bone marrow-derived cells as progenitors of lung alveolar epithelium // Development. 2001. Vol.128, №24. Р.5181-5188.

29. Krampera M., Pasini A., Pizzolo G., Cosmi L., Romagnani S., Annunziato F. Regenerative and immunomodulatory potential of mesenchymal stem cells // Curr. Opin. Pharmacol. 2006. Vol.6, №4. Р.435-441. doi: 10.1016/j.coph.2006.02.008

30. Le Blanc K., Pittenger M. Mesenchymal stem cells: progress toward promise // Cytotherapy. 2005. Vol.7, №1. Р.36-45. doi:10.1080/14653240510018118

31. Lederer D., Arcasoy S. Update in surgical therapy for chronic obstructive pulmonary disease // Clin. Chest. Med. 2007. Vol.28, №3. Р.639-653. doi:10.1016/j.ccm.2007.05.004

32. Li J., Li D., Liu X., Tang S., Wei F. Human umbilical cord mesenchymal stem cells reduce systemic inflammation and attenuate LPS-induced acute lung injury in rats // J. Inflamm. (Lond). 2012. Vol.9, №1. Р.33-43. doi:10.1186/1476-9255-9-33

33. Liu A., Liu L., Chen S., Yang Y., Zhao H., Liu L., Guo F., Lu X., Qiu H. Activation of canonical wnt pathway promotes differentiation of mouse bone marrow-derived MSCs into type II alveolar epithelial cells, confers resistance to oxidative stress, and promotes their migration to injured lung tissue in vitro // J. Cell. Physiol. 2013. Vol.228, №6. Р.1270-1283. doi: 10.1002/jcp.24282

34. Martinez F., Chang A. Surgical therapy for chronic obstructive pulmonary disease // Semin. Respir. Crit. Care. Med. 2005. Vol.26, №2. Р.167-191. doi: 10.1055/s-2005-869537

35. Moodley Y., Atienza D., Manuelpillai U., Samuel C., Tchongue J., Ilancheran S., Boyd R., Trounson A. Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury // Am. J. Pathol. 2009. Vol.175, №1. Р.303-313. doi: 10.2353/ajpath.2009.080629

36. Nascimento L.F., Vieira L.C., Mantovani K.C., Moreira D.S. Air pollution and respiratory diseases: ecological time series // Sao Paulo Med. J. 2016. Vol.134, №4. Р.315-321. doi: 10.1590/1516-3180.2015.0237250216

37. Osthoff M., Jenkins C., Leuppi J. Chronic obstructive pulmonary disease - a treatable disease // Swiss Med. Wkly. 2013. Vol.143. P.w13777. doi: 10.4414/smw.2013.13777

38. Putcha N., Drummond M.B., Wise R.A., Hansel N.N. Comorbidities and chronic obstructive pulmonary disease: prevalence, influence on outcomes, and management // Semin. Respir. Crit. Care Med. 2015. Vol.36, №4. Р.575-591. doi: 10.1055/s-0035-1556063

39. Rojas M., Xu J., Woods C., Mora A., Spears W., Roman J., Brigham K. Bone marrow-derived mesenchymal stem cells in repair of the injured lung // Am. J. Respir. Cell Mol. Biol. 2005. Vol.33, №2. Р.145-152. doi: 10.1165/rcmb.2004-0330OC

40. Shigemura N., Okumura M., Mizuno S., Imanishi Y., Matsuyama A., Shiono H., Nakamura T., Sawa Y. Lung tissue engineering technique with adipose stromal cells improves surgical outcome for pulmonary emphysema // Am. J. Respir. Crit. Care. Med. 2006. Vol.174, №11. Р.1199-1205. doi: 10.1164/rccm.200603-406OC

41. Tseluyko S.S., Kushnarev V.A. Regenerative biological medicine: achievements and prospects // Amur Medical Journal. 2016. Vol.1, №13. P.7-15.

42. Siedlinski M., Postma D., van Diemen C., Blokstra A., Smit H., Boezen H. Lung function loss, smoking, vitamin c intake, and polymorphisms of the glutamate-cysteine ligase genes // Am. J. Respir. Crit. Care. Med. 2008. Vol.178, №1. Р.13-19. doi: 10.1164/rccm.200711-1749OC

43. Stoller J., Panos R., Krachman S., Doherty D., Make B. Oxygen therapy for patients with COPD: current evidence and the long-term oxygen treatment trial // Chest. 2010. Vol.138, №1. Р. 179-187. doi:10.1378/chest.09-2555

44. Tropea K., Leder E., Aslam M., Lau A., Raiser D., Lee J., Balasubramaniam V., Fredenburgh L., Alex Mitsialis S., Kourembanas S., Kim C. Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia // Am. J. Physiol. Lung Cell. Mol. Physiol. 2012. Vol.302, №9. Р.L829-L837. doi: 10.1152/ajplung.00347.2011

45. Vestbo J., Hurd S., Agustí A., Jones P., Vogelmeier C., Anzueto A., Barnes P., Fabbri L., Martinez F., Nishimura M., Stockley R., Sin D., Rodriguez-Roisin R. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary // Am. J. Respir. Crit. Care. Med. 2013. Vol.187, №4. Р.347-365. doi: 10.1164/rccm.201204-0596PP

46. Wecht S., Rojas M. Mesenchymal stem cells in the treatment of chronic lung disease // Respirology. 2016. Vol.21, №8. Р.1366-1375. doi: 10.1111/resp.12911

47. Weiss D., Casaburi R., Flannery R., LeRoux-Williams M., Tashkin D. A placebo-controlled, randomized trial of mesenchymal stem cells in COPD // Chest. 2013. Vol.143, №6. Р.1590-1598. doi: 10.1378/chest.12-2094

48. Wong A., Dutly A., Sacher A., Lee H., Hwang D., Liu M., Keshavjee S., Hu J., Waddell T. Targeted cell replacement with bone marrow cells for airway epithelial regeneration // Am. J. Physiol. Lung Cell. Mol. Physiol. 2007. Vol.293, №3. Р.L740-L752. doi:10.1152/ajplung.00050.2007

49. Woods J., Wheeler J., Finch C., Pinner N. Corticosteroids in the treatment of acute exacerbations of chronic obstructive pulmonary disease // Int. J. Chron. Obstruct. Pulmon. Dis. 2014. Vol.9. Р.421-430. doi: 10.2147/COPD.S51012

50. Zhao Y., Xu A., Xu Q., Zhao W., Li D., Fang X., Ren Y. Bone marrow mesenchymal stem cell transplantation for treatment of emphysemic rats // Int. J. Clin. Exp. Med. 2014. Vol.7, №4. Р.968-972.

51. Zhen G., Liu H., Gu N., Zhang H., Xu Y., Zhang Z. Mesenchymal stem cells transplantation protects against rat pulmonary emphysema // Front. Biosci. 2008. №13. Р.3415-3422. doi: 10.2741/2936

52. Zhen G., Xue Z., Zhao J., Gu N., Tang Z., Xu Y., Zhang Z. Mesenchymal stem cell transplantation increases expression of vascular endothelial growth factor in papain-induced emphysematous lungs and inhibits apoptosis of lung cells // Cytotherapy. 2010. Vol.12, №5. Р.605-614. doi: 10.3109/14653241003745888

53. Zhou Y., Zhong N., Li X., Chen S., Zheng J., Zhao D., Yao W., Zhi R., Wei L., He B., Zhang X., Yang C., Li Y., Li F., Du J., Gui J., Hu B., Bai C., Huang P., Chen G., Xu Y., Wang C., Liang B., Li Y., Hu G., Tan H., Ye X., Ma X., Chen Y., Hu X., Tian J., Zhu X., Shi Z., Du X., Li M., Liu S., Yu R., Zhao J., Ma Q., Xie C., Li X., Chen T., Lin Y., Zeng L., Ye C., Ye W., Luo X., Zeng L., Yu S., Guan W., Ran P. Tiotropium in early-stage chronic obstructive pulmonary disease // N. Engl. J. Med. 2017. Vol.377, №10. Р.923-935. doi: 10.1056/NEJMoa1700228


Review

For citations:


Tseluyko S.S., Yatsenko A.A., Leonov D.V., Ustinov E.M., Kushnarev V.A. ROLE OF MESENCHYMAL STEM CELLS IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (REVIEW). Bulletin Physiology and Pathology of Respiration. 2018;(70):121-128. (In Russ.) https://doi.org/10.12737/article_5c127a27ba9a85.88292840

Views: 149


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1998-5029 (Print)