The condition of the hepatobiliary system in newborns from mothers with chronic simple bronchitis in remission and risk of miscarriage

The aim of the work was to study the state of the hepatobiliary system in newborns from mothers with chronic simple bronchitis in remission and the threat of miscarriage. Liver function was studied in 100 full-term newborns from mothers with uncomplicated pregnancy and mothers suffering from chronic simple bronchitis without exacerbation. The first group included 30 children whose mothers had a physiological course of pregnancy, the second one had 38 newborns from mothers with chronic simple bronchitis without exacerbation during gestation, the third group consisted of 32 children with antenatal ontogenesis, complicated with chronic simple bronchitis in remission and the threat of miscarriage in the second trimester of pregnancy. In the blood of newborns in the second group there was a decrease in total protein to 58.3±1.01 g/L (in the first group it was 64.2±1.07 g/L, р<0.001); at the same time there were no significant differences in the content of albumins, total, indirect and direct bilirubin, as well as total cholesterol, high and low density lipoproteins (LDLP) and triglycerides (p>0.05). The lower values of total protein (52.1±1.06 g/L; p<0.001) were recorded in the third group compared with the first group, at the same time there was registered the increase in total bilirubin (32.1±1.58 and 25.4±1.67 pmol/L, respectively; р1<0,01) and indirect bilirubin (30.1±1.54 and 23.3±1.66 pmol/L, respectively; p<0.01), the decrease in total cholesterol (1.84±0.05 and 2.02±0.07 mmol/L, respectively; p<0.05) and LDLP (0.26±0.03 and 0.52±0.03 mmol/L, respectively; p<0.001), as well as the growth in the concentration of triglycerides (0.53±0.03 and 0.43±0.03 mmol/L, respectively; p<0.05). Attention was drawn to the lower concentration of LDLP in the third group compared with the second (0.26±0.03 and 0.44±0.03 mmol/L, respectively; p<0.001). The results indicate an important role of chronic simple bronchitis without exacerbation, combined with the development of the threat of miscarriage in women in the second trimester of pregnancy, in disturbance of the functional state of the hepatobiliary system in their newborns.

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