Clinical and radiological features of organizing pneumonia (a review of the literature, personal clinical observations)

Organizing pneumonia (OP), formerly known as obliterating bronchitis with organizing pneumonia, is a form of idiopathic interstitial pneumonia. There are two forms of OP: predominant (90%) cryptogenic (unknown in etiology) organizing pneumonia and secondary pneumonia affiliated to other mainly interstitial diseases. Cryptogenic OP is believed to be a consequence of alveolar damage and is characterized by the formation of organized buds of the granulation tissue that prevent alveolar lumen and bronchioles, which in its turn leads to respiratory failure. The organization of pneumonia is a pathological diagnosis and it can be secondary to the identified etiology. Cryptogenic OP should be diagnosed only after the exclusion of any other possible etiology.

This report, along with a review of the world literature in the historical aspect, presents modern achievements in the diagnosis and management of patients. The possibilities of multispiral computed tomography with extensive use of basic image postprocessing are emphasized. Personal experience of clinical and radiological diagnostics and differential diagnostics of idiopathic interstitial pneumonia and, in particular, OP is systematized. Diagnostic (clinical and radiological) patterns have been developed and demonstrated in practical work.

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