THE ROLE OF GROWTH FACTORS IN TROPHOBLAST INVASION AND THEIR ASSOCIATION WITH THE PATHOLOGICAL COURSE OF PREGNANCY
https://doi.org/10.36604/1998-5029-2019-74-111-118
Abstract
The article presents a brief review of the literature on the role of growth factors in the processes of trophoblast invasion and their association with the pathological course of pregnancy. The importance of vascular endothelial growth factor, placental growth factor and vessels receptors, transforming growth factor, insulin-like growth factor in the development and differentiation of the placenta during physiological pregnancy are shown. There has been described violations that allow to assert the involvement of vascular growth factors and their receptors in the pathogenesis of placental insufficiency, preeclampsia, spontaneous miscarriage, fetal growth retardation. The analysis of the literature data concerning the role of growth factors in the processes of trophoblast invasion and various complications of the gestational period allowed to draw a conclusion about the insufficient study of this issue.
About the Author
N. G. Prikhodko
Far Eastern Scientific Center of Physiology and Pathology of Respiration
Russian Federation
Russian Federation
MD, Postgraduate Student, Laboratory of Mechanisms of Etiopathogenesis and Recovery Processes of the Respiratory System at Non-Specific Lung Diseases
22 Kalinina Str., Blagoveshchensk, 675000, Russian Federation
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63. Prosler J., Chen Q., Chamley L., James J.L. The relationship between TGFbeta, low oxygen and the outgrowth of extravillous trophoblasts from anchoring villi during the first trimestr of pregnancy. Cytokine 2014; 68(1):9–15. doi:10.1016/j.cyto.2014.03.001
64. Sahu M.B., Deepak V., Gonzales S.K., Rimawi B., Watkins K.K., Smith A.K., Badell M.L., Sidell N., Rajakumar A. Decidual cells from women with preeclampsia exhibit inadequate decidualization and reduced sFlt1 suppression. Pregnancy Hypertens. 2019; 15:64–71. doi:10.1016/j.preghy.2018.11.003
65. Shchyogolev A.L., Dubova E.A., Pavlova K.A., Lyapin V.M., Sukhikh G.T. Expression of antiangiogenic factors in the placental structures in pre-eclampsia. Bull. Exp. Biol. Med. 2012; 154(2):287–291. doi:10.1007/s10517-012-1932-0
66. Su M.T., Lin S.H., Chen Y.C. Genetic association studies of angiogenesis and vasoconstriction-related genes in women with recurrent pregnancy loss: a systematic review and meta-analysis. Hum. Reprod. Update 2011; 17(6):803–812. doi:10.1093/humupd/dmr027
67. Venkata Surekha M., Singh S., Sarada K., Sailaja G., Balakrishna N., Srinivas M., Uday Kumar P. Study on the effect of severity of maternal iron deficiency anemia on regulators of angiogenesis in placenta. Fetal Pediatr. Pathol. 2019; 38(5):361–375. doi:10.1080/15513815.2019.1587120
68. Visan V., Scripcariu I.S., Socolov D., Costescu A., Rusu D., Socolov R., Avasiloaiei A., Boiculese L., Dimitriu C. Better prediction for FGR (fetal growth restriction) with the sFlt-1/PIGF ratio: A case-control study. Medicine (Baltimore) 2019; 98(26):e16069. doi:10.1097/MD.0000000000016069
69. Wang P., Fan J., Chen Z., Meng Z.Q., Meng Z.Q., Luo J.M., Lin J.H., Zhou Z.H., Chen H., Wang K., Xu Z.D., Liu L.M. Low-level expression of Smad7 correlates with lymph node metastasis and poor prognosis in patients with pancreatic cancer. Ann. Surg. Oncol. 2009; 16(4):826–835. doi:10.1245/s10434-008-0284-5
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For citations:
Prikhodko N.G. THE ROLE OF GROWTH FACTORS IN TROPHOBLAST INVASION AND THEIR ASSOCIATION WITH THE PATHOLOGICAL COURSE OF PREGNANCY. Bulletin Physiology and Pathology of Respiration. 2019;(74):111-118. (In Russ.) https://doi.org/10.36604/1998-5029-2019-74-111-118
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