STRUCTURAL AND FUNCTIONAL DISTURBANCES OF LIVER IN THE SETTING OF EXPERIMENTAL PNEUMONIA
Abstract
To study the effect of pneumonia on function and structure of liver we investigated the histological status of the liver, lysosome activity in the liver homogenate, aminotransferases activity, total protein and total bilirubin levels in serum. Sephadex-pneumonia in a rat model (intratracheal injection of Sephadex А-25 at a concentration of 5 mg/kg body weight) lead to elevated serum level of aminotransferases and total bilirubin level, to decreased total protein level in serum, to appeared histological markers of liver dysfunction. Sephadex-pneumonia induced the activation of lysosome (the elevation of free lysosome enzyme activity) for adaptation liver cells in setting of experimental pneumonia in rat. But the injury of lysosome membrane and lysosomal leakage with increase of nonsedimentational level of lysosome enzyme activity in rat liver homogenate and elevation of serum acid phosphatase and cathepsin D activites is one of the reasons of liver damage.
About the Author
Лариса Вохминцева
Новосибирский государственный медицинский университет
Russian Federation
Russian Federation
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STRUCTURAL AND FUNCTIONAL DISTURBANCES OF LIVER IN THE SETTING OF EXPERIMENTAL PNEUMONIA. Bulletin Physiology and Pathology of Respiration. 2007;(26):52-55. (In Russ.)
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