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Synthesis of sex steroid hormones in placenta (review)

Abstract

The references review about the process of sex steroid hormones synthesis during pregnancy is analyzed in the article. The stages of cholesterol transforming into progesterone and estrogens in fetoplacental complex are studied in detail, enzymes involved in biosynthesis are also examined, and the latest data about the process regulation are given.

Keywords


579.222.3:577.175.632/.64:618.36

About the Author

Inna V. Dovzhikova
Far Eastern Science Centre Physiology And Pathology Of Respiration
Russian Federation


References

1. Богданович Р.Н., Берестовая Т.А., Лукьянов П.А. Значение определения гормонов фетоплацентарной системы и трофобластического β1-гликопротеина у беременных с угрозой невынашивания для диагностики плацентарной недостаточности // Рос. вестн. акушера-гинеколога. 2005. Т.5, №6. С.3-7.

2. Содержание прогестерона и его производных в крови во время нормальной беременности и нормальных родов / Бунятин А.Ф. [и др.] // Акуш. и гин. 1983. №8. С.14-15.

3. Довжикова И.В. Ферменты стероидогенеза (обзор литературы) // Бюлл. физиол. и патол. дыхания. 2010. Вып.37. С.60-64.

4. Смирнов А.Н. Элементы эндокринной регуляции. М.: ГЭОТАР-Медиа, 2006. 352 с.

5. Современные вопросы эндокринологии. Стероидные гормоны / под ред. Н.А.Юдаева. М.: Медицина, 1969. 184 с.

6. Референтные значения 17-гидроксипрогестерона и дегидроэпиандростерон-сульфата в период гестации / Суплотова Л.А. [и др.] // Пробл. эндокринол. 2007. Т.53, №4. С.19-22.

7. Цирельников Н.И. Гистофизиология плаценты человека. Новосибирск: Наука, 1980. 184 с.

8. Ясинская И.М., Сумбаев В.В. Универсальная и комплексная энзимология ароматазы // Пробл. эндокринол. 2006. Т.52, №1. С.39-47.

9. Expression of the genes for 3 beta-hydroxysteroid dehydrogenase type 1 and cytochrome P450scc during syncytium formation by human placental cytotrophoblast cells in culture and the regulation by progesterone and estradiol / Beaudoin C. [et al.] // J. Endocrinol. 1997. Vol.154, №3. P.379-387.

10. Beck J.S., Ewen S.W. The persistence of «steroid-synthesizing cell» antigen and 3β-hydrohysteroid dehydrogenase in organ cultures of normal human placentas // Brit. J. Exp. Pathol. 1970. Vol.51, №2. P.171-178.

11. Bentele W. Harhoöstrogene und placentare Funktionsleietung. Abhsndi // Dtsch. Acad. D. Wiss. Berlin. Kl. Med. 1965. №1. S.131-135.

12. Goldberger R.F., Yamamoto K.R. Biological Regulation and Development: Hormone Action. New York: Plenum Publishing Corp., 1984. 482 p.

13. Studies on the mode of action luteinzing hormone and chorionic gonadotropin on estrogenic biosynthesis and glucogenolysis by human placenta percused in vitro / Cedard L. [et al.] // Steroids. 1970. Vol.16, №4. P.361-376.

14. Chaudhary J., Bhattacharyya S., Das C. Regulation of progesterone secretion in human syncytiotrophoblast in culture by human chorionic gonadotropin // J. Steroid Biochem. Mol. Biol. 1992. Vol.42, №3-4. P.425-432.

15. Diczfalusy E. Endocrine functions of human fetoplacental unit // Federation Proc. 1964. №23. P.791-798.

16. Diczfalusy E., Pion R., Schwers J. Steroid biogenesis and metabolism in the human foeto-placental unit at midpregnancy // Arch. Anat. Microsc. et Morphol. Exp. 1965. Vol.54, №1. P.67-82.

17. Diczfalusy E. Steroid metabolism in the human foeto-placental unit // Acta endocrinol. 1969. Vol.61, №4. P.649-664.

18. Localization of 17 beta-hydroxysteroid dehydrogenase throughout gestation in human placenta / Dupont E. [et al.] // J. Histochem. and Cytochem. 1991. Vol.39, №10. Р.1403-1407.

19. Easterling W.E., Talbert L.M. Estriol excretion in normal and complicated pregnancies // Am. J. Obstet. Gynec. 1970. Vol.107, №3. P.417-422.

20. Goebelsmann U. Protein and steroid hormones in pregnancy // J. Reprod. Med. 1979. Vol.23, №4. P.116-177.

21. Grossman S., Bloch E. Comparative placental steroid synthesis // Steroids. 1973. Vol.21, №6. P.813-820.

22. Hirai M., Masubuchi Y., Komoriyama K. Endocrino-pharmacolgical study of reproduction: role and biosynthesis of steroid hormones in the feto-placental unit // Nippon Yakuriqaku Zasshi. 1981. Vol.77, №3. P.231-244.

23. Histochemical and biochemical investigations of 3β-hydroxy-A-steroid dehydrogenase in the chorion, adrenals and gonads of human fetuses / Jirasek J.E. [et al.] // Endocrinology. 1969. Vol.54, №3-4. P.173-178.

24. Theoretical studies on the mechanism of conversion of androgens to estrogens by aromatase / Korzekwa K.R. [et al.] // Biochemistry. 1991. Vol. 30, №25. P.6155-6162.

25. Luu-The V. Analysis and characteristics of multiple types of human 17β-hydroxysteroid dehydrogenase // J. Steroid Biochem. Mol. Biol. 2001. Vol.76, №1. P.143-151.

26. Regulation of expression of the 3 beta-hydroxysteroid dehydrogenases of human placenta and fetal adrenal / Mason J.I <http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Search&Term=%22Mason%20JI%22%5BAuthor%5D&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstract>. [et al.] // J. Steroid Biochem. Mol. Biol. <javascript:AL_get(this,%20'jour',%20'J%20Steroid%20Biochem%20Mol%20Biol.');> 1993. Vol.47, №1-6. Р.151-159.

27. Miller W.L. Molecular biology of steroid hormone synthesis // Endocr. Rev. 1988. Vol.9, №3. P.295-318.

28. Endocrine Regulation of Human Fetal Growth: The Role of the Mother, Placenta, and Fetus / Murphy V.E. [et al.] // Endocr. Rev. 2006. Vol. 27, №2. P.141-169.

29. Payne A.H., Hales D.B. Overview of Steroidogenic Enzymes in the Pathway from Cholesterol to Active Steroid Hormones // Endocr. Rev. 2004. Vol.25, №6. P.947-970.

30. Studies on the metabolism of c-21 steroids in the human foetoplacental unit. I. Formation of α,β-unsaturated 3-Ketones in midterm placentas perfused in situ with pregnenolone and 17-hydroxypregnenolone / Pion R. [et al.] // Acta endocrinol. 1965. Vol.48, №2. P.234-248.

31. Reves-Romero M.A. The physiological role of estriol during human fetal development is to act as antioxidant at lipophilic milieus of the central nervous system // Medical Hypotheses. 2001. Vol.56, №1. P.107-109.

32. Schwers J., Eriksson G., Diczfalusy E. Metabolism of oesterone and oestradiol in the human foeto-placental unit at mildpregnancy // Acta endocrinol. 1965. Vol.49, №1. P.65-82.

33. Human Cytosolic 3{alpha}-Hydroxysteroid dehydrogenases of the Aldo-keto Reductase Superfamily Display Significant 3{beta}-Hydroxysteroid dehydrogenase Activity: implications for steroid hormone metabolism and action / Steckelbroeck S. [et al.] // J. Biol. Chem. 2004. Vol.279, №11. P.10784-10795.

34. Stemmler H.J. Endocrine relationship between mother and foetus // Klin. Wschr. 1960. №3. P.97-103.

35. Strauss J.F., Martinez F., Kiriakidou M. Placental steroid hormone synthesis: unique features and unanswered questions // Biology of reproduction. 1996. Vol.54. P.303-311.

36. Townsley J.D. Inhibition of placental 3β-hydroxy-steroid dehydrogenase by naturally occurring steroids. А potential mechanism regulating oestrogen synthesis from unconjugated precursors // Acta Endocrinol. 1975. Vol.79, №4. Р.740-748.

37. Tremblay Y. Beaudoin C. Regulation of 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase messenger ribonucleic acid level by cyclic AMP and phorbol myristate acetate in human choriocarcinoma cells // Mol. Endocrinol. 1993. Vol.7. P.355-364.

38. Tuckey R.С., McKinley A.J., Headlam M.J. Oxidized adrenoxin acts as a competitive inhibitor of cytochrome P450scc in mitochondria from the human placenta// FEBS J. 2001. Vol.268, №8. P.2338-2343.

39. Tuckey R. С. Progesterone synthesis by the human placenta // Placenta. 2005. Vol.26, №4. P.273-281.

40. Characterization and identification of steroid sulfate transporters of human placenta / Ugele B. [et al.] // Am. J. Physiol. Endocrinol. Metab. 2003. Vol.284, №2. Р. E390-E398.

41. Varangot J., Cerard L., Jonnotti S. Perfusion in the human placenta in vitro. Study of the biosynthesis of estrogens // Am. J. Obstet. Gynec. 1965. Vol.92, №4. Р.334-337.


Review

For citations:


Dovzhikova I.V. Synthesis of sex steroid hormones in placenta (review). Bulletin Physiology and Pathology of Respiration. 2011;(41):85-88. (In Russ.)

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ISSN 1998-5029 (Print)