CLINICAL SUGNIFICANCE OF MEASURING OF OXIDATIVE STRESS PARAMETERS IN THE EXHALED BREATH CONDENSATE IN PATIENTS WITH BRONCHIAL ASTHMA
Abstract
The examination of 98 patients with bronchial asthma and 10 practically healthy volunteers was done. The dynamics of oxidative stress parameters in the exhaled breath condensate and the blood serum in dependence on the severity degree of a disease and the level of asthma control was studied. It was established that patients with bronchial asthma had much higher concentration of Н2О2 in the exhaled breath condensate than in the healthy persons, which closely correlates with the bronchi patency. Alongside with the growth of the disease severity degree, the increase of diene conjugates of Н2О2 in the exhaled breath condensate as well as malonic dialdehyde in the blood serum was found out. Not depending on the severity degree as soon as the control over asthma was lost, patients had the growth of Н2О2 concentration in the exhaled breath condensate and of malonic dialdehyde in the blood serum as well as the decrease of endogenous vitamin E.
About the Authors
Nelli M. Goryachkina
Far Eastern Science centre physiology and pathology of respiration
Russian Federation
Russian Federation
Xiangdong Zhou
The Second Affiliated Hospital of Chongqing Medical University
Russian Federation
Russian Federation
Qi Li
Respiratory Department of the Second Affiliated Hospital of Chongqing Medical University, China
Russian Federation
Russian Federation
Evgeny A. Borodin
Amur State Medical Academy of the Ministry of the Russian Federation, Blagoveshchensk
Russian Federation
Russian Federation
Julius M. Perelman
Far Eastern Science centre physiology and pathology of respiration
Russian Federation
Russian Federation
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Review
For citations:
Goryachkina N.M., Zhou X., Li Q., Borodin E.A., Perelman J.M. CLINICAL SUGNIFICANCE OF MEASURING OF OXIDATIVE STRESS PARAMETERS IN THE EXHALED BREATH CONDENSATE IN PATIENTS WITH BRONCHIAL ASTHMA. Bulletin Physiology and Pathology of Respiration. 2011;(42):8-12. (In Russ.)
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