THERMOSENSITIVE ION CHANNELS TRPM8 (REVIEW)
Abstract
The ability to perceive temperature provides the basis for adaptive responses aimed at the active elimination of the threat or of the disturbance in temperature homeostasis. During last decades some members of transient receptor potential (TRP) cation channels family have been identified as thermoreceptors. Recent studies indicate their possible involvement in a number of physiological processes and pathological states. Moreover, it has been confirmed by now that thermosensitive TRP channels are capable to mediate certain respiratory responses. This review contains modern data on genetics, molecular structure and regulation of TRPM8-the ion channel activated by cold temperatures.
Keywords
616-001.18:612.014.462:612.55
About the Author
Denis E. Naumov
Far Eastern Science centre physiology and pathology of respiration
Russian Federation
Russian Federation
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Review
For citations:
Naumov D.E. THERMOSENSITIVE ION CHANNELS TRPM8 (REVIEW). Bulletin Physiology and Pathology of Respiration. 2011;(42):89-96. (In Russ.)
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