THE INFLUENCE OF STANDARD BASE THERAPY ON THE DYNAMICS OF OXIDATIVE STRESS INDICATORS IN PATIENTS WITH BRONCHIAL ASTHMA AND COLD AIRWAY HYPERRESPONSIVENESS
Abstract
66 patients with bronchial asthma and cold airway hyperresponsiveness and 15 healthy people were examined. The dynamics of oxidative stress indicators in the exhaled breath condensate before and after the test with cold air and also after two-week standard base therapy was studied. It was established that patients with bronchial asthma with cold airway hyperresponsiveness had a much higher concentration of Н2О2 and diene conjugates in exhaled breath condensate than in the control group. After the test with cold air they had an increase of Н2О2, of diene conjugates, of ketodienes and of conjugated triens in exhaled breath condensate. After standard base therapy there was a significant drop of base Н2О2, and there was high bronchi responsiveness to cold air and the growth of oxidative stress indicators after the test of isocapnic hyperventilation with cold air.
Keywords
bronchial asthma,
oxidative stress,
cold airway hyperresponsiveness,
exhaled breath condensate,
base therapy
616.248-08:612.225
About the Authors
Nelli M. Smirnova
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation
Russian Federation
Yuliy M. Perel'man
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation
Russian Federation
Anna G. Prikhod'ko
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation
Russian Federation
Evgeniy A. Borodin
Amur State Medical Academy
Russian Federation
Russian Federation
Il'ya Z. Batkin
Khabarovsk Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration of Siberian Branch RAMS - Research Institute of Maternity and Childhood Protection
Russian Federation
Russian Federation
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Review
For citations:
Smirnova N.M., Perel'man Yu.M., Prikhod'ko A.G., Borodin E.A., Batkin I.Z. THE INFLUENCE OF STANDARD BASE THERAPY ON THE DYNAMICS OF OXIDATIVE STRESS INDICATORS IN PATIENTS WITH BRONCHIAL ASTHMA AND COLD AIRWAY HYPERRESPONSIVENESS. Bulletin Physiology and Pathology of Respiration. 2012;(43):19-22. (In Russ.)
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