PATHOGENETIC FEATURES OF PHENOTYPES OF ASTHMA AT THE RESORT STAGE OF MEDICAL REHABILITATION
https://doi.org/10.12737/article_59acb3dfda63a1.35626963
Abstract
The aim of the study is to describe pathogenetic features of phenotypes of asthma at a resort stage of medical rehabilitation. 300 patients with asthma who arrived on the Southern coast of the Crimea (Yalta) for medical rehabilitation were examined. As a result of the study 7 phenotypes of asthma at a resort stage of medical rehabilitation were distinguished. Asthma phenotypes created by the cluster analysis are pathological conditions of patients which were caused by different pathogenetic mechanisms. Each phenotype of asthma is characterized only by its peculiar pathogenetic features in the form of the manifestation of a different degree and relation of clinical changes and functional indices of airway obstruction, an allergic (eosinophilic) inflammation, a condition of physical working capacity and the quality of life taking into account the gender of patients, their body weight, an age of a disease debut and features of application of medications. The established pathogenetic mechanisms of each asthma phenotypes can be considered when individual programs of medical rehabilitation at the resort are formed
About the Authors
L. Sh. Dudchenko
Academician Research Institute of Physical Methods of Treatment, Medical Climatology and Rehabilitation named after I.M. Sechenov
Russian Federation
Russian Federation
S. N. Belyaeva
Academician Research Institute of Physical Methods of Treatment, Medical Climatology and Rehabilitation named after I.M. Sechenov
Russian Federation
Russian Federation
G. G. Maslikova
Academician Research Institute of Physical Methods of Treatment, Medical Climatology and Rehabilitation named after I.M. Sechenov
Russian Federation
Russian Federation
S. I. Koval'chuk
Academician Research Institute of Physical Methods of Treatment, Medical Climatology and Rehabilitation named after I.M. Sechenov
Russian Federation
Russian Federation
V. M. Savchenko
Medical Academy named after S.I. Georgievsky of Vernadsky Crimean Federal University
Russian Federation
Russian Federation
References
1. Загидулин Ш.З., Галимова Е.С., Суховская О.А., Ежова Г.Ю. Оценка качества жизни у пациентов с обострением бронхиальной астмы // Пульмонология. 2013. №1. С.49-53. doi: http://dx.doi.org/10.18093/0869-0189-2013-0-1-49-53
2. Трухачева Н.В. Математическая статистика в медико-биологических исследованиях с применением пакета Statistica. М.: ГЭОТАР-Медиа, 2012. 383 с.
3. Bel E.N. Clinical phenotypes of asthma // Curr. Opin. Pulm. Med. 2004. Vol.10, №1. Р.44-50.
4. Chung K.F., Bel E.H., Wenzel S.E. Difficult-to-Treat Severe Asthma. European Respiratory Society Monograph. 2011. Vol.51. doi: 10.1183/1025448x.erm5110
5. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Updated 2012. URL: http://www.ginasthma.org
6. Green R.H., Brightling C.E., McKenna S., Hargadon B., Parker D., Bradding P., Wardlaw A.J., Pavord I.D. Asthma exacerbation and sputum eosinophil counts: a randomized controlled trial // Lancet. 2002. Vol.360, №9347. Р.1715-1721.
7. Rice J.P., Saccone N.L., Rasmussen E. Definition of the phenotype // Adv. Genet. 2001. Vol.42. Р.69-76.
8. Roth M., Zhong J., Zumkeller C., S'ng C.T., Goulet S., Tamm M. The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodeling // PLoS One. 2013. Vol.8, №2. Р.56015.
9. The ENFUMOSA cross-sectional European multicenter study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma // Eur. Respir. J. 2003. Vol.22, №3. Р.470-477.
10. Ware, J.E., Snow, K.K., Kosinski, M., Gandek B. SF-36 health survey: manual and interpretation guide. Second printing. Boston: The Health Institute, New England Medical Center, 1993.
11. Wenzel S. Severe asthma: from characteristics to phenotypes to endotypes // Clin. Exp. Allergy. 2012. Vol.42, №5. Р.650-658.
Review
For citations:
Dudchenko L.Sh., Belyaeva S.N., Maslikova G.G., Koval'chuk S.I., Savchenko V.M. PATHOGENETIC FEATURES OF PHENOTYPES OF ASTHMA AT THE RESORT STAGE OF MEDICAL REHABILITATION. Bulletin Physiology and Pathology of Respiration. 2017;(65):38-42. (In Russ.) https://doi.org/10.12737/article_59acb3dfda63a1.35626963
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