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CORTISOL CONTENT AT HERPES VIRUS INFECTION EXACERBATION AT EARLY PREGNANCY

Abstract

The aim of the research is to study cortisol content in placenta in exacerbation of herpes virus infection at early pregnancy and to identify the reasons for its change. 98 samples of abortion material of 5-10 weeks of development taken from almost healthy women and women with herpes virus infection exacerbation were examined. The study was done with the help of biochemical identification of cortisol concentration and histochemical analysis of the 11β-hydroxysteroid dehydrogenase of I and II types. At exacerbation of herpes virus infection a significant increase of cortisol content (more than two times) in villous chorions at early stages of pregnancy was found out. The revealed changes were the result of the hormone metabolism disturbance: low activity of 11β-hydroxysteroid dehydrogenase of II type and high activity of 11β-hydroxysteroid dehydrogenase of I type in placenta, as well as inadequacy of reactions regulatory mechanisms.

Keywords


577.175.534:618.2:616.523-036.65

About the Authors

Inna V. Dovzhikova
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation


Mikhail T. Lutsenko
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation


Irina A. Andrievskaya
Far Eastern Scientific Center of Physiology and Pathology of Respiration SB RAMS
Russian Federation


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Review

For citations:

Dovzhikova I.V., Lutsenko M.T., Andrievskaya I.A. CORTISOL CONTENT AT HERPES VIRUS INFECTION EXACERBATION AT EARLY PREGNANCY. Bulletin Physiology and Pathology of Respiration. 2012;(44):69-74.

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