PATHOGENESIS OF CHANGES OF BLOOD FLOW IN UTERINE ARTEIRIES AND OF ULTRASOUND PICTURE OF CHORION AT INFLUENZA А(Н3N2) IN WOMEN IN THE FIRST TRIMESTER OF PREGNANCY

Abstract

The blood flow in uterine arteries, ultrasound picture of chorion, biochemical and hormonal parameters of 135 women in the first trimester of pregnancy at influenza А(Н3N2) in the period of the disease epidemic were studied. It was established that patients with antibody titer to the pathogen 1:32-1:128 in comparison with the titer 1:8-1:32 had a statistically reliable increase of the resistance in uterine arteries, the visualization frequency growth of uterus hyper tonus till 29.4%, of thinning of chorion till 26.5%, of its thickening till 58.8%, of retoplacental hematoma till 22.1%, of deformation of the fetal egg till 25% at the rise of mean-molecular peptides till 0.25±0.002 units of opt. dens. (р<0.001) and seromucoid till 0.12±0.002 units of opt. dens. (p<0.01). There was an activation of lipid peroxidation with the increase of malonic dialdehyde concentration and the drop of ά-tocopherol level. The oppression of hormonopoiesis in the mother's organism and in the chorion was revealed through the concentration drop of chorionic gonadotropin, placental lactogen, progesterone, estriol, dehydroepiandrosterone against the growth of serotonin and cortisol. It was found out that the increase of aggressiveness of influenza А(Н3N2), endotoxemia, activation of lipid peroxidation and serotoninemia play an important role in the pathogenesis of blood flow and echostructure of chorion changes and they condition the damage of the wall of blood vessels of a mother and chorion villi.