VASCULAR STIFFNESS AND GLOMERULAR FILTRATION RATE IN PATIENTS WITH BRONCHIAL ASTHMA

The features of vascular stiffness and glomerular filtration rate (GFR) depending on the severity degree and the control level of the diseases were studied in 48 patients with bronchial asthma (BA). The state of the vascular stiffness was studied with the method of sphygmomanometry and sphygmography (Pulse Wave Velocity (PWV) was found), Ankle-Brachial Index (ABI) and GFR were identified with the help of Cockroft-Gault formula. According to the severity of the disease the first group included 8 patients with mild persistent BA, the second group had 23 patients with the moderate BA and 17 patients with severe BA were in the third group. According to the level of control the patients were divided into the group with partly controlled BA (8 patients) and uncontrolled BA (40 patients). It was found out that PVW in the first group didn't differ from the values that were in the group of healthy volunteers (7.4±0.6 and 6.1±03 m/s, respectively), but in the second and the third groups it increased reliably till 10.9±1.7 m/s (р<0.01) and 12.7±3.3 m/s (р<0.05), respectively. At controlled and uncontrolled BA the values of PVW grew till 9.3±2.5 m/s (p<0.05) and 11.3±1.6 m/s (р<0.01), respectively. This fact may point to the increase of cardiovascular risk at BA. The parameters of ABI did not have statistically significant differences with the control group. The values of GFR dropped in all the groups, most significantly at severe BA (64.24±1.98 ml/min, р<0.05) and uncontrolled BA (76.43±3.37 ml/min, р<0.001). The direct dependence of GFR decrease on the length of the disease was revealed. So, at severe uncontrolled long course of BA there is a significant drop of GFR, which is the result of attrition of kidneys compensatory possibilities about the maintenance of effective filtration pressure in consequence of persistent disturbances of renal blood flow. The worsening of glomerular filtration conditions in the future may lead to a significant disturbance of kidney's function and poor prognosis in patients with severe BA.

bronchial asthma, vascular stiffness, pulse wave velocity, ankle-brachial index, glomerular filtration rate

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